Prkcz - protein kinase C, zeta Gene

Rattus norvegicus

Also known as Pkcz; r14-3-3; 14-3-3-zetaisoform

Gene ID: 25522 | Gene type: protein coding

About Prkcz

Primary_assembly 5: 165,819,466-165,930,367 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 205 orthologues, 9 paralogues and is associated with 23 phenotypes. Biased expression in Brain (RPKM 18.1), Kidney (RPKM 59.9) and 7 other tissues.

Summary

Enables several functions, including 14-3-3 protein binding activity; Enzyme binding activity; and protein kinase C activity. Involved in several processes, including activation of Phospholipase D activity; activation of protein kinase B activity; and positive regulation of cell communication. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and stress fiber. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcz Products(1)

mRNA	Protein	Name
NM_022507.1	NP_071952.1	protein kinase C zeta type

Prkcz Protein Structure

PB1_aPKC

C1_aPKC_zeta

STKc_aPKC_zeta

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

protein kinase C zeta type

nPKC-zeta

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11141	PRKCZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11142	Prkcz Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11143	Prkcz Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcz	NCBI	NCBI:5590

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