2. Gene
  3. RNF144B - ring finger protein 144B Gene

RNF144B - ring finger protein 144B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PIR2; IBRDC2; p53RFP; bA528A10.3

Gene ID: 255488 | Gene type: protein coding

About RNF144B

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:18,387,350-18,468,870 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 9 paralogues. Broad expression in thyroid (RPKM 30.0), lung (RPKM 13.0) and 20 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF144B Products(1)

mRNA Protein Name
NM_182757.4 NP_877434.2 E3 ubiquitin-protein ligase RNF144B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12853982 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
12853982 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
20300062 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
12853982 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20300062 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
20300062 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF144B Protein Structure

IBR

IBR: IBR domain, a half RING-finger domain (103 - 166)

IBR

IBR: IBR domain, a half RING-finger domain (188 - 225)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF144B

IBR domain containing 2

RNF144B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RNF144B Q7Z419 UBE2L6 Homo sapiens O14933
Y2H Array
19549727
Intra
RNF144B Q7Z419 UBE2L6 Homo sapiens O14933
Y2H Array
19690564
Intra
RNF144B Q7Z419 TP73 Homo sapiens O15350
Anti Tag CoIP
20615966
Intra
RNF144B Q7Z419 BAX Homo sapiens Q07812
IF
20300062
Intra
RNF144B Q7Z419 TP73 Homo sapiens O15350-8
Anti Tag CoIP
20615966
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12054 RNF144B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RNF144B VGNC VGNC:104424
Mus musculus RNF144B MGD MGI:2384986
Canis familiaris RNF144B VGNC VGNC:45636
Bos taurus RNF144B VGNC VGNC:34027
Felis catus RNF144B VGNC VGNC:102505
Rattus norvegicus RNF144B RGD RGD:1308856