SLC2A3 - solute carrier family 2 member 3 Gene

Rattus norvegicus

Also known as GLUT3

Gene ID: 25551 | Gene type: protein coding

About SLC2A3

Primary_assembly 4: 155,960,946-156,025,472 reverse strand.mRatBN7.2:CM026977.1

This gene has 3 transcripts (splice variants), 254 orthologues, 12 paralogues and is associated with 20 phenotypes. Biased expression in Testes (RPKM 617.3), Brain (RPKM 246.8) and 6 other tissues.

Summary

Enables several functions, including dehydroascorbic acid transmembrane transporter activity; galactoside binding activity; and monosaccharide binding activity. Involved in several processes, including dehydroascorbic acid transport; glucose import; and response to Thyroglobulin triiodothyronine. Located in caveola and synaptic vesicle membrane. Is active in glutamatergic synapse. Is integral component of synaptic membrane. Biomarker of cataract and hypertension. Orthologous to human SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Apr 2022]

SLC2A3 Products(2)

mRNA	Protein	Name
NM_017102.3	NP_058798.2	solute carrier family 2, facilitated glucose transporter member 3 isoform 1
NM_001412552.1	NP_001399481.1	solute carrier family 2, facilitated glucose transporter member 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose binding	IDA IDA: Inferred from direct assay	8645164	RGD
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	15320870	RGD
enables dehydroascorbic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	18668520	RGD
enables galactoside binding	IDA IDA: Inferred from direct assay	8645164	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	16419038	RGD
enables monosaccharide transmembrane transporter activity	IDA IDA: Inferred from direct assay	8645164	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16419038	RGD
enables xylose binding	IDA IDA: Inferred from direct assay	8645164	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import	IDA IDA: Inferred from direct assay	15320870	RGD
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	18668520	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	16581179	RGD
involved in dehydroascorbic acid transport	IDA IDA: Inferred from direct assay	18668520	RGD
involved in monosaccharide transmembrane transport	IDA IDA: Inferred from direct assay	8645164	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15320870	RGD
involved in response to Thyroglobulin triiodothyronine	IEP IEP: Inferred from expression pattern	16581179	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	12882795	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	16419038	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	18668520	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21307237	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18668520	RGD
is active in synaptic membrane	IDA IDA: Inferred from direct assay	21307237	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	10318820	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A3 Protein Structure

MFS_GLUT_Class1

0
100
200
300
400
495 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 3

GLUT-3	Solute carrier family 2 A3 (neuron glucose transporter)
glucose transporter type 3, brain	solute carrier family 2 (facilitated glucose transporter), member 3
solute carrier family 2, facilitated glucose transporter member 3-like	solute carrier family 2, member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13167	SLC2A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13168	Slc2a3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13169	SLC2A3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	SLC2A3	NCBI	NCBI:6515

Name
Email *

	Sorry, but the email address you supplied was invalid.