SLC2A3 - solute carrier family 2 member 3 Gene

Homo sapiens

Also known as GLUT3

Gene ID: 6515 | Gene type: protein coding

About SLC2A3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,919,230-7,936,187 (from NCBI)

This gene has 11 transcripts (splice variants), 491 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 183.0), placenta (RPKM 54.5) and 11 other tissues.

Summary

Enables dehydroascorbic acid transmembrane transporter activity; glucose binding activity; and glucose transmembrane transporter activity. Involved in glucose import across plasma membrane and transport across blood-brain barrier. Is integral component of plasma membrane. Biomarker of Alzheimer's disease; acanthosis nigricans; diabetes mellitus; and type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]

SLC2A3 Products(1)

mRNA	Protein	Name
NM_006931.3	NP_008862.1	solute carrier family 2, facilitated glucose transporter member 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose binding	IDA IDA: Inferred from direct assay	26176916	GOA
enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	8457197	GOA
enables dehydroascorbic acid transmembrane transporter activity	EXP EXP: Inferred from Experiment	9228080	GOA
NOT enables fructose transmembrane transporter activity	IDA IDA: Inferred from direct assay	8457197	GOA
enables galactose transmembrane transporter activity	IDA IDA: Inferred from direct assay	8457197	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import across plasma membrane	IGI IGI: Inferred from genetic interaction	23975336	GOA
involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	8457197	GOA
NOT involved in fructose transmembrane transport	IDA IDA: Inferred from direct assay	8457197	GOA
involved in galactose transmembrane transport	IDA IDA: Inferred from direct assay	8457197	GOA
involved in transport across blood-brain barrier	IGI IGI: Inferred from genetic interaction	23975336	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	26176916	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	9477959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A3 Protein Structure

Sugar_tr

0
100
200
300
400
496 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 3

GLUT-3	glucose transporter type 3, brain
solute carrier family 2 (facilitated glucose transporter), member 3

SLC2A3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC2A3	P11169	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SLC2A3	P11169	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SLC2A3	P11169	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC2A3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83177	Glucose Transporter GLUT3 Antibody (YA2922)	WB	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Huntington Disease

Huntington'S Disease	Huntington Chorea
HD	Huntington'S Chorea
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Acanthosis Nigricans

Keratosis Nigricans

Fetal Macrosomia

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Diabetes Mellitus

Diabetes

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Choriocarcinoma

Chorioepithelioma

Hyperglycemia

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Brain Edema

Intracranial Swelling	Wet Brain
Cerebral Edema

Gestational Diabetes

Gestational Diabetes Mellitus	GDM
Diabetes Mellitus Arising In Pregnancy	Maternal Gestational Diabetes Mellitus
Diabetes Mellitus, Gestational	Diabetes Mellitus, Pregnancy Related
Diabetes, Pregnancy-Induced	Diabetes Gestational
Diabetes, Gestational	Diabetes Of Pregnancy
Gdm - [Gestational Diabetes Mellitus]	Gestational Diabetes Mellitus Nos
Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Micronodular Basal Cell Carcinoma

Skin Micronodular Basal Cell Carcinoma

Basal Cell Carcinoma, Micronodular

Persistent Fetal Circulation Syndrome

Fetal Circulation	Persistent Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13167	SLC2A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13168	Slc2a3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13169	SLC2A3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC2A3	RGD	RGD:3706
Mus musculus	SLC2A3	MGD	MGI:95757

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