SMCO1 - single-pass membrane protein with coiled-coil domains 1 Gene

Homo sapiens

Also known as C3orf43

Gene ID: 255798 | Gene type: protein coding

About SMCO1

This gene has 2 transcripts (splice variants) and 103 orthologues. Restricted expression toward heart (RPKM 14.0).

Summary

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SMCO1 Products(2)

mRNA	Protein	Name
NM_001077657.3	NP_001071125.1	single-pass membrane and coiled-coil domain-containing protein 1 isoform 1
NM_001320473.2	NP_001307402.1	single-pass membrane and coiled-coil domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMCO1 Protein Structure

DUF4547

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

single-pass membrane and coiled-coil domain-containing protein 1

SMCO1 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMCO1	Q147U7	FNDC8	Homo sapiens	Q8TC99	Y2H Array	32296183
Intra	SMCO1	Q147U7	FNDC8	Homo sapiens	Q8TC99	Y2H Prey Pooling	32296183
Intra	SMCO1	Q147U7	FNDC8	Homo sapiens	Q8TC99	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Subvalvular Aortic Stenosis

Fixed Subaortic Stenosis	Subaortic Stenosis
Aortic Stenosis, Subvalvular

Chromosome 3q29 Deletion Syndrome

Chromosome 3q29 Microdeletion Syndrome	3q29 Microdeletion Syndrome
3q Subtelomere Deletion Syndrome	3q29 Recurrent Deletion
3qter Deletion	3q29 Deletion Syndrome
Monosomy 3q29	Microdeletion 3q29 Syndrome
Del(3)(Q29)	Monosomy 3qter
3q29 Deletion	Del3q29

Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency	IMD46
Cid Due To Tfrc Deficiency	Combined Immunodeficiency Due To Tfrc Deficiency

Meningocele

Isolated Spina Bifida	Spina Bifida
Cleft Spine	Open Spine
Rachischisis	Spinal Dysraphism
Spinal Meningocele	Congenital Meningocele

Nephronophthisis 3

NPHP3	Nph3
Adolescent Nephronophthisis	Nephronophthisis, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS13424	SMCO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SMCO1	VGNC	VGNC:102846
Canis familiaris	SMCO1	VGNC	VGNC:46549
Bos taurus	SMCO1	VGNC	VGNC:35005
Rattus norvegicus	SMCO1	RGD	RGD:1562500
Mus musculus	SMCO1	MGD	MGI:1916826

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