Plau - plasminogen activator, urokinase Gene

Rattus norvegicus

Also known as UPAM

Gene ID: 25619 | Gene type: protein coding

About Plau

Summary

Enables peptidase activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to staurosporine; and positive regulation of ovulation. Located in extracellular space and membrane. Used to study several diseases, including alcoholic liver cirrhosis; lung disease (multiple); sciatic neuropathy; status epilepticus; and transient cerebral ischemia. Biomarker of brain disease (multiple); end stage renal disease; myocardial infarction; sciatic neuropathy; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]

Plau Products(1)

mRNA	Protein	Name
NM_013085.3	NP_037217.3	urokinase-type plasminogen activator precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	2509088	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	15854129	RGD
involved in cellular response to fluid shear stress	IEP IEP: Inferred from expression pattern	19166201	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	17953365	RGD
involved in cellular response to hepatocyte growth factor stimulus	IEP IEP: Inferred from expression pattern	19834131	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	19490965	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19184369	RGD
involved in cellular response to staurosporine	IEP IEP: Inferred from expression pattern	19137075	RGD
involved in embryo implantation	IEP IEP: Inferred from expression pattern	15019809	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16899994	RGD
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	16456094	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	9315743	RGD
involved in regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	17587687	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	22592543	RGD
involved in response to hepatocyte growth factor	IEP IEP: Inferred from expression pattern	21843593	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19099788	RGD
involved in skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	12919869	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	17712486	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10727258	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

urokinase-type plasminogen activator

U-plasminogen activator	Urinary plasminogen activator, urokinase
uPA	urokinase plasminogen activator

Recombinant Plau Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73561	PLAU/uPA Protein, Rat (HEK293, His)	Q3KR76/NP_037217.3 (G20-F432)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10647	PLAU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plau	NCBI	NCBI:5328
Macaca fascicularis	Plau	NCBI	NCBI:102135886
Mus musculus	Plau	NCBI	NCBI:18792

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