PLAU/uPA Protein, Rat (HEK293, His)

PLAU/uPA proteins are characterized by a lack of conserved residues critical for feature annotation propagation, raising interesting questions about their structural and functional aspects. This uniqueness suggests potential differences in molecular interactions in plasminogen activation and fibrinolysis regulation. PLAU/uPA Protein, Rat (HEK293, His) is the recombinant rat-derived PLAU/uPA protein, expressed by HEK293 , with C-His labeled tag.

PLAU, also known as uPA (urokinase-type plasminogen activator), is distinguished by the absence of conserved residue(s) necessary for the propagation of feature annotation. This unique characteristic raises intriguing questions about the structural and functional aspects of PLAU, suggesting potential distinctions in its molecular interactions within the context of plasminogen activation and the regulation of fibrinolysis. The absence of these conserved residues underscores the specific attributes of PLAU and underscores the need for in-depth investigations to elucidate its distinctive roles in cellular processes and pathological conditions.

Human uPAR, hFc Tag captured on CM5 Chip via Protein A can bind Rat PLAU, His Tag with an affinity constant of 4.31 μM as determined in SPR assay (Biacore T200).

Rat

HEK293

C-His

Q3KR76/NP_037217.3 (G20-F432)

25619  [NCBI]

30-35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.