Prkaca - protein kinase cAMP-activated catalytic subunit alpha Gene

Rattus norvegicus

Also known as PKCA1; Cs-PKA

Gene ID: 25636 | Gene type: protein coding

About Prkaca

Primary_assembly 19: 24,155,090-24,178,430 reverse strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 289 orthologues, 4 paralogues and is associated with 13 phenotypes. Biased expression in Heart (RPKM 789.1), Adrenal (RPKM 386.4) and 9 other tissues.

Summary

Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including circadian sleep/wake cycle, REM sleep; regulation of glutamatergic synaptic transmission; and spontaneous exocytosis of neurotransmitter. Located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and presynapse. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkaca Products(1)

mRNA	Protein	Name
NM_001100922.2	NP_001094392.1	cAMP-dependent protein kinase catalytic subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	11907174	RGD
enables cAMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	17190793	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18381233	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11035810	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12672265	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	23419316	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of meiotic cell cycle	IDA IDA: Inferred from direct assay	16816331	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15546918	RGD
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	17190793	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23349233	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11907174	RGD
involved in regulation of cellular respiration	IDA IDA: Inferred from direct assay	12562968	RGD
involved in regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	12562968	RGD
involved in spontaneous exocytosis of neurotransmitter	IMP IMP: Inferred from mutant phenotype	17190793	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	11907174	RGD
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	11716788	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18550536	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	11716788	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	11716788	RGD
located in presynapse	IMP IMP: Inferred from mutant phenotype	17190793	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12672265	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkaca Protein Structure

STKc_PKA

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase catalytic subunit alpha

PKA C-alpha	cAMP-dependent protein kinase catalytic subunit C alpha
protein kinase A	protein kinase, cAMP-dependent, alpha catalytic subunit
protein kinase, cAMP-dependent, catalytic, alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153967	BLU0588	Inhibitor	95.92%	Unkown
HY-150076	BLU2864	Inhibitor	99.24%	Unkown
HY-150072	DS89002333	Inhibitor	99.87%	Unkown
HY-150072B	(R)-DS89002333		98.74%	Unkown
HY-150072A	(2S,4R)-DS89002333		/	Unkown
HY-150073	DS01080522	Inhibitor	/	Unkown
HY-RS11104	PRKACA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11105	Prkaca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11106	Prkaca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkaca	NCBI	NCBI:5566
Canis familiaris	Prkaca	NCBI	NCBI:403556

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