PRKACA - protein kinase cAMP-activated catalytic subunit alpha Gene

Homo sapiens

Also known as CAFD1; PKACA; PPNAD4

Gene ID: 5566 | Gene type: protein coding

About PRKACA

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,091,688-14,117,762 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 289 orthologues, 5 paralogues and is associated with 62 phenotypes. Ubiquitous expression in heart (RPKM 62.0), adrenal (RPKM 43.9) and 25 other tissues.

Summary

This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and Apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

PRKACA Products(5)

mRNA	Protein	Name
NM_001304349.2	NP_001291278.1	cAMP-dependent protein kinase catalytic subunit alpha isoform 3
XM_047439070.1	XP_047295026.1	cAMP-dependent protein kinase catalytic subunit alpha isoform X2
NM_207518.3	NP_997401.1	cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha2
XM_017026948.2	XP_016882437.1	cAMP-dependent protein kinase catalytic subunit alpha isoform X1
NM_002730.4	NP_002721.1	cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	11029056	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11035810	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	12475942	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11035810	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	22797923	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21085490	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	26537248	GOA
enables protein serine/threonine/tyrosine kinase activity	IDA IDA: Inferred from direct assay	22797923	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	21423175	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	38503280	GOA
involved in cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	21812984	GOA
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	19949837	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	21085490	GOA
involved in mRNA processing	IDA IDA: Inferred from direct assay	17594903	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	31112131	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	10805756	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	26537248	GOA
involved in positive regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	38503280	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12475942	GOA
involved in regulation of bicellular tight junction assembly	IDA IDA: Inferred from direct assay	15905176	GOA
involved in regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	19949837	GOA
involved in regulation of proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	17565987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with axoneme	IDA IDA: Inferred from direct assay	12475942	GOA
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	12475942	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21085490	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	17594903	GOA
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	21812984	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21085490	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21085490	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15569306	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	17911601	GOA
located in sperm midpiece	IDA IDA: Inferred from direct assay	10906071	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKACA Protein Structure

Pkinase

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase catalytic subunit alpha

PKA C-alpha	protein kinase A catalytic subunit
protein kinase, cAMP-dependent, alpha catalytic subunit	protein kinase, cAMP-dependent, catalytic, alpha

PRKACA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKACA	P17612	PKIB	Homo sapiens	Q9C010-2	Y2H Array	32296183
Intra	PRKACA	P17612	PKIB	Homo sapiens	Q9C010-2	Y2H Prey Pooling	32296183
Intra	PRKACA	P17612	PKIB	Homo sapiens	Q9C010-2	Validated Y2H	32296183
Intra	PRKACA	P17612	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	PRKACA	P17612	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	PRKACA	P17612	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	PRKACA	P17612	PRKAR1B	Homo sapiens	P31321	Protein Kinase Assay	24605759
Intra	PRKACA	P17612	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
Intra	PRKACA	P17612	PRKAR1B	Homo sapiens	P31321	TAP	23455922
Intra	PRKACA	P17612	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	PRKACA	P17612	PRKAR1B	Homo sapiens	P31321	Pull Down	32707033
Intra	PRKACA	P17612	PRKAR1B	Homo sapiens	P31321	Anti Tag CoIP	35271311
Intra	PRKACA	P17612	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	TAP	23455922
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	Pull Down	32707033
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	Anti Tag CoIP	35271311
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	Pull Down	17148597
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	Validated Y2H	27107012
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	Complementation	32296183
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	Validated Y2H	32296183
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	Protein Kinase Assay	24605759
Intra	PRKACA	P17612	PRKAR2B	Homo sapiens	P31323	BFG-2H	27107012
Intra	PRKACA	P17612	HSP90AA1	Homo sapiens	P07900	TAP	23455922
Intra	PRKACA	P17612	ITGAV	Homo sapiens	P06756	Validated Y2H	32814053
Intra	PRKACA	P17612	ITGAV	Homo sapiens	P06756	Y2H Array	32814053
Intra	PRKACA	P17612	ITGAV	Homo sapiens	P06756	Y2H Pooling	32814053
Intra	PRKACA	P17612	YWHAZ	Homo sapiens	P63104	Protein Kinase Assay	16376338
Intra	PRKACA	P17612	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
Intra	PRKACA	P17612	BAG2	Homo sapiens	O95816	Anti Bait CoIP	35167623
Intra	PRKACA	P17612	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	11035810
Intra	PRKACA	P17612	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PRKACA	P17612	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PRKACA	P17612	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PRKACA	P17612	PTN	Homo sapiens	P21246	Validated Y2H	32814053
Intra	PRKACA	P17612	PTN	Homo sapiens	P21246	Y2H Array	32814053
Intra	PRKACA	P17612	PTN	Homo sapiens	P21246	Y2H Pooling	32814053
Intra	PRKACA	P17612	PRKAR1A	Homo sapiens	P10644	TAP	23455922
Intra	PRKACA	P17612	PRKAR1A	Homo sapiens	P10644	Anti Tag CoIP	24855271
Intra	PRKACA	P17612	PRKAR1A	Homo sapiens	P10644	Pull Down	32707033
Intra	PRKACA	P17612	PRKAR1A	Homo sapiens	P10644	Anti Tag CoIP	35271311
Intra	PRKACA	P17612	PRKAR1A	Homo sapiens	P10644	FRET	25477193
Intra	PRKACA	P17612	PRKAR1A	Homo sapiens	P10644	Protein Kinase Assay	24605759
Intra	PRKACA	P17612	AKIP1	Homo sapiens	Q9NQ31	Pull Down	15630084
Intra	PRKACA	P17612	LRRK2	Homo sapiens	Q5S007	Anti Bait CoIP	24464040
Intra	PRKACA	P17612	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24351927
Intra	PRKACA	P17612	PNP	Homo sapiens	P00491	Validated Y2H	32814053
Intra	PRKACA	P17612	PNP	Homo sapiens	P00491	Y2H Array	32814053
Intra	PRKACA	P17612	PNP	Homo sapiens	P00491	Y2H Pooling	32814053
Intra	PRKACA	P17612	DPYSL4	Homo sapiens	O14531	Y2H Pooling	32814053
Intra	PRKACA	P17612	DPYSL4	Homo sapiens	O14531	Validated Y2H	32814053
Intra	PRKACA	P17612	DPYSL4	Homo sapiens	O14531	Y2H Array	32814053
Intra	PRKACA	P17612	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	PRKACA	P17612	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	PRKACA	P17612	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	PRKACA	P17612	ALOX5	Homo sapiens	P09917	Protein Kinase Assay	24860872
Intra	PRKACA	P17612	AVPI1	Homo sapiens	Q5T686	Y2H Prey Pooling	32296183
Intra	PRKACA	P17612	AVPI1	Homo sapiens	Q5T686	Validated Y2H	32296183
Intra	PRKACA	P17612	AVPI1	Homo sapiens	Q5T686	Y2H Array	32296183
Intra	PRKACA	P17612	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PRKACA	P17612	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	PRKACA	P17612	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PRKACA	P17612	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053
Intra	PRKACA	P17612	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	PRKACA	P17612	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Cross	PRKACA	P17612	Prkar2b	Rattus norvegicus	P12369	Anti Bait CoIP	24464040

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKACA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81127	PKA alpha + beta Antibody	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse

Related Diseases

Diseases

Alias

Primary Pigmented Nodular Adrenocortical Disease

Ppnad	Primary Pigmented Nodular Adrenal Dysplasia
Pigmented Nodular Adrenocortical Disease, Primary, 2	Pigmented Nodular Adrenocortical Disease, Primary, 1

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Cardioacrofacial Dysplasia 1

CAFD1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Brachydactyly

Acth-Independent Cushing Syndrome

Adrenal Cushing Syndrome	Adrenocorticotropic Hormone-Independent Cushing Syndrome
Corticotropin-Independent Cushing Syndrome

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Atrioventricular Septal Defect

AVSD	Atrioventricular Canal Defect
Avcd	Endocardial Cushion Defect
Ecd	Avc Defect
Atrioventricular Septal Defect, Susceptibility To, 1	Atrioventricular Septal Defect 1
Endocardial Cushion Defects	Septal Defect, Atrioventricular
Atrioventricular Defect With Atrial Shunting Only	Incomplete Atrioventricular Septal Defect With Isolated Atrial Component
Incomplete Atrioventricular Canal Defect With Isolated Atrial Component	Primum Atrial Septal Defect
Partial Atrioventricular Canal Defect With Isolated Atrial Component	Partial Atrioventricular Septal Defect, Ostium Primum Type
Ostium Primum Atrial Septal Defect	Partial Atrioventricular Canal Defect
Partial Atrioventricular Septal Defect	Atrial Septum Primum Defect
Atrioventricular Canal Defect With Isolated Ventricular Component	Atrioventricular Canal Defect With Isolated Ventricular Communication
Atrioventricular Septal Defect With Isolated Ventricular Component	Atrioventricular Septal Defect With Atrial Shunting And Restrictive Ventricular Shunting
Intermediate Atrioventricular Canal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valve	Transitional Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valves
Atrioventricular Canal Defect Associated With A Restrictive Ventricular Septal Defect	Intermediate Atrioventricular Canal Defect
Intermediate Atrioventricular Septal Defect With Atrial And Ventricular Components And Separate Atrioventricular Valvar Orifices	Intermediate Atrioventricular Septal Defect
Transitional Atrioventricular Canal Defect	Transitional Atrioventricular Septal Defect
Complete Atrioventricular Canal With Atrial And Ventricular Components	Complete Atrioventricular Canal Defect
Complete Atrioventricular Septal Defect

Pigmented Nodular Adrenocortical Disease, Primary, 4

PPNAD4	Chromosome 19p13 Duplication Syndrome
Cushing Syndrome, Adrenal, Due To Ppnad4	Primary Pigmented Nodular Adrenocortical Disease 4
Adrenal Cushing Syndrome Due To Ppnad4	Adrenocortical Disease, Nodular, Pigmented, Primary, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153967	BLU0588	Inhibitor	95.92%	Unkown
HY-150076	BLU2864	Inhibitor	99.24%	Unkown
HY-150072	DS89002333	Inhibitor	99.87%	Unkown
HY-150072B	(R)-DS89002333		98.74%	Unkown
HY-150072A	(2S,4R)-DS89002333		/	Unkown
HY-150073	DS01080522	Inhibitor	/	Unkown
HY-RS11104	PRKACA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11105	Prkaca Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11106	Prkaca Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRKACA	VGNC	VGNC:59441
Felis catus	PRKACA	VGNC	VGNC:69048
Mus musculus	PRKACA	MGD	MGI:97592
Macaca mulatta	PRKACA	VGNC	VGNC:76403
Bos taurus	PRKACA	VGNC	VGNC:50250
Rattus norvegicus	PRKACA	RGD	RGD:3389
Others	PRKACA	NCBI

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