EML3 - EMAP like 3 Gene

Homo sapiens

Also known as ELP95; EMAP3; EMAP95

Gene ID: 256364 | Gene type: protein coding

About EML3

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,602,218-62,612,775 (from NCBI)

This gene has 18 transcripts (splice variants), 194 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues.

Summary

Predicted to enable microtubule binding activity. Involved in mitotic metaphase plate congression and regulation of mitotic spindle assembly. Located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

EML3 Products(4)

mRNA	Protein	Name
NM_001300793.2	NP_001287722.1	echinoderm microtubule-associated protein-like 3 isoform 1
NM_001300794.2	NP_001287723.1	echinoderm microtubule-associated protein-like 3 isoform 2
NM_001411016.1	NP_001397945.1	echinoderm microtubule-associated protein-like 3 isoform 4
NM_153265.3	NP_694997.2	echinoderm microtubule-associated protein-like 3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25740311	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	18445686	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	30723163	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18445686	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	18445686	GOA
located in midbody	IDA IDA: Inferred from direct assay	18445686	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18445686	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EML3 Protein Structure

HELP

WD40

0
200
400
600
800
896 a.a.

Protein Preferred Names

Protein Names

echinoderm microtubule-associated protein-like 3

EMAP-3

EML3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EML3	Q32P44	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	EML3	Q32P44	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	EML3	Q32P44	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	EML3	Q32P44	ATXN1	Homo sapiens	P54253	Y2H Array	32296183
Intra	EML3	Q32P44	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04355	EML3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EML3	VGNC	VGNC:72120
Bos taurus	EML3	VGNC	VGNC:28477
Mus musculus	EML3	MGD	MGI:2387612
Felis catus	EML3	VGNC	VGNC:61850
Canis familiaris	EML3	VGNC	VGNC:40348
Rattus norvegicus	EML3	RGD	RGD:7630023

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