2. Gene
  3. DDIT4L - DNA damage inducible transcript 4 like Gene

DDIT4L - DNA damage inducible transcript 4 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as REDD2; Rtp801L

Gene ID: 115265 | Gene type: protein coding

About DDIT4L

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:100,185,870-100,190,468 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues and 1 paralogue. Biased expression in prostate (RPKM 12.6), kidney (RPKM 5.8) and 10 other tissues.

Summary

Predicted to be involved in negative regulation of signal transduction. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DDIT4L Products(1)

mRNA Protein Name
NM_145244.4 NP_660287.1 DNA damage-inducible transcript 4-like protein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDIT4L Protein Structure

RTP801_C

RTP801_C: RTP801 C-terminal region (65 - 183)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

DNA damage-inducible transcript 4-like protein

HIF-1 responsive protein RTP801-like

DDIT4L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra DDIT4L Q96D03 CATIP Homo sapiens Q7Z7H3
Y2H Array
32296183
Intra DDIT4L Q96D03 TRIM74 Homo sapiens Q86UV6-2
Y2H Prey Pooling
32296183
Intra DDIT4L Q96D03 TRIM74 Homo sapiens Q86UV6-2
Y2H Array
32296183
Intra DDIT4L Q96D03 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 NUDT22 Homo sapiens Q9BRQ3
Validated Y2H
32296183
Intra DDIT4L Q96D03 CABP5 Homo sapiens Q9NP86
Validated Y2H
32296183
Intra DDIT4L Q96D03 NGB Homo sapiens Q9NPG2
Validated Y2H
32296183
Intra DDIT4L Q96D03 ARHGEF3 Homo sapiens Q9NR81
Validated Y2H
32296183
Intra DDIT4L Q96D03 NUDT11 Homo sapiens Q96G61
Validated Y2H
32296183
Intra DDIT4L Q96D03 TARS2 Homo sapiens Q9BW92
Validated Y2H
32296183
Intra DDIT4L Q96D03 CHMP1A Homo sapiens Q9HD42
Validated Y2H
32296183
Intra DDIT4L Q96D03 SCOC Homo sapiens Q9UIL1-3
Validated Y2H
32296183
Intra DDIT4L Q96D03 NXT2 Homo sapiens Q9NPJ8-3
Validated Y2H
32296183
Intra DDIT4L Q96D03 MEMO1 Homo sapiens Q9Y316
Validated Y2H
32296183
Intra DDIT4L Q96D03 PUF60 Homo sapiens Q9UHX1-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 EMILIN1 Homo sapiens Q9Y6C2-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra DDIT4L Q96D03 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 BANF2 Homo sapiens Q9H503-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 CPNE7 Homo sapiens Q9UBL6-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 XPNPEP1 Homo sapiens Q9NQW7-3
Validated Y2H
32296183
Intra DDIT4L Q96D03 PITX2 Homo sapiens Q99697-2
Validated Y2H
32296183
Intra DDIT4L Q96D03 TFPT Homo sapiens P0C1Z6
BFG-2H
27107012
Intra DDIT4L Q96D03 TFPT Homo sapiens P0C1Z6
Validated Y2H
27107012
Intra DDIT4L Q96D03 NHLRC4 Homo sapiens P0CG21
Y2H Array
32296183
Intra DDIT4L Q96D03 NHLRC4 Homo sapiens P0CG21
Y2H Prey Pooling
32296183
Intra DDIT4L Q96D03 BCL2L14 Homo sapiens Q9BZR8
Validated Y2H
32296183
Intra DDIT4L Q96D03 PLAA Homo sapiens Q9Y263
Validated Y2H
32296183
Intra DDIT4L Q96D03 TCP11L1 Homo sapiens Q9NUJ3
Validated Y2H
32296183
Intra DDIT4L Q96D03 PPIL1 Homo sapiens Q9Y3C6
Validated Y2H
32296183
Intra DDIT4L Q96D03 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra DDIT4L Q96D03 WHRN Homo sapiens Q9P202
Validated Y2H
32296183
Intra DDIT4L Q96D03 LSM7 Homo sapiens Q9UK45
Validated Y2H
32296183
Intra DDIT4L Q96D03 LSM7 Homo sapiens Q9UK45
Y2H Array
25416956
Intra DDIT4L Q96D03 LSM7 Homo sapiens Q9UK45
Y2H Array
32296183
Intra DDIT4L Q96D03 LSM7 Homo sapiens Q9UK45
Y2H Array
31515488
Intra DDIT4L Q96D03 LSM7 Homo sapiens Q9UK45
Validated Y2H
25416956
Intra DDIT4L Q96D03 LSM7 Homo sapiens Q9UK45
Y2H Prey Pooling
32296183
Intra DDIT4L Q96D03 VBP1 Homo sapiens P61758
Y2H Prey Pooling
32296183
Intra DDIT4L Q96D03 VBP1 Homo sapiens P61758
Y2H Array
32296183
Intra DDIT4L Q96D03 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra DDIT4L Q96D03 EXOSC1 Homo sapiens Q9Y3B2
Validated Y2H
32296183
Intra DDIT4L Q96D03 LSM5 Homo sapiens Q9Y4Y9
Validated Y2H
32296183
Intra DDIT4L Q96D03 SEPTIN5 Homo sapiens Q99719
Validated Y2H
32296183
Intra DDIT4L Q96D03 ACY3 Homo sapiens Q96HD9
Validated Y2H
32296183
Intra DDIT4L Q96D03 TSSK3 Homo sapiens Q96PN8
MAPPIT
32296183
Intra DDIT4L Q96D03 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra DDIT4L Q96D03 PARVG Homo sapiens Q9HBI0
Validated Y2H
32296183
Intra DDIT4L Q96D03 MORF4L2 Homo sapiens Q15014
Y2H Array
25416956
Intra DDIT4L Q96D03 MORF4L2 Homo sapiens Q15014
Y2H Prey Pooling
25416956
Intra DDIT4L Q96D03 IL36RN Homo sapiens Q9UBH0
Validated Y2H
32296183
Intra DDIT4L Q96D03 SH3BGRL3 Homo sapiens Q9H299
Validated Y2H
32296183
Intra DDIT4L Q96D03 PBK Homo sapiens Q96KB5
Validated Y2H
32296183
Intra DDIT4L Q96D03 PSMB9 Homo sapiens P28065
Y2H Prey Pooling
32296183
Intra DDIT4L Q96D03 PSMB9 Homo sapiens P28065
Y2H Array
32296183
Intra DDIT4L Q96D03 MIEN1 Homo sapiens Q9BRT3
Validated Y2H
32296183
Intra DDIT4L Q96D03 SNRPG Homo sapiens P62308
MAPPIT
32296183
Intra DDIT4L Q96D03 SNRPG Homo sapiens P62308
Validated Y2H
32814053
Intra DDIT4L Q96D03 SNRPG Homo sapiens P62308
Y2H Array
32814053
Intra DDIT4L Q96D03 SNRPG Homo sapiens P62308
Y2H Pooling
32814053
Intra DDIT4L Q96D03 NIBAN1 Homo sapiens Q9BZQ8
Validated Y2H
32296183
Intra DDIT4L Q96D03 MYLIP Homo sapiens Q8WY64
Y2H Array
32296183
Intra DDIT4L Q96D03 MYLIP Homo sapiens Q8WY64
Y2H Prey Pooling
32296183
Intra DDIT4L Q96D03 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Intra DDIT4L Q96D03 DCTPP1 Homo sapiens Q9H773
Validated Y2H
32296183
Intra DDIT4L Q96D03 DUSP23 Homo sapiens Q9BVJ7
Validated Y2H
32296183
Intra DDIT4L Q96D03 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra DDIT4L Q96D03 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Intra DDIT4L Q96D03 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
32296183
Intra DDIT4L Q96D03 HSPB7 Homo sapiens Q9UBY9
Validated Y2H
32296183
Intra DDIT4L Q96D03 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra DDIT4L Q96D03 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra DDIT4L Q96D03 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Intra DDIT4L Q96D03 C19orf25 Homo sapiens Q9UFG5
Validated Y2H
32296183
Intra DDIT4L Q96D03 TCF19 Homo sapiens Q9Y242
Validated Y2H
32296183
Intra DDIT4L Q96D03 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra DDIT4L Q96D03 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra DDIT4L Q96D03 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra DDIT4L Q96D03 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra DDIT4L Q96D03 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra DDIT4L Q96D03 STAC3 Homo sapiens Q96MF2
Validated Y2H
32296183
Intra DDIT4L Q96D03 TOLLIP Homo sapiens Q9H0E2
Validated Y2H
32296183
Intra DDIT4L Q96D03 NAA10 Homo sapiens P41227
MAPPIT
32296183
Intra DDIT4L Q96D03 RPRD1B Homo sapiens Q9NQG5
Validated Y2H
32296183
Intra DDIT4L Q96D03 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Intra DDIT4L Q96D03 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Intra DDIT4L Q96D03 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Intra DDIT4L Q96D03 TBC1D22B Homo sapiens Q9NU19
Y2H Array
32296183
Intra DDIT4L Q96D03 MLX Homo sapiens Q9UH92-3
Validated Y2H
32296183
Intra DDIT4L Q96D03 LRATD2 Homo sapiens Q96KN1
Validated Y2H
32296183
Intra DDIT4L Q96D03 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brain Germinoma

Intracranial Germinoma

Germinoma Of The Brain
Lung Pleomorphic Carcinoma
Zika Fever

Zika Virus Infection

Zika Virus Disease

Zika Virus

Zika Virus Fever

Mosquito-Borne Viral Fever, Zika
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DDIT4L VGNC VGNC:39838
Felis catus DDIT4L VGNC VGNC:61391
Rattus norvegicus DDIT4L RGD RGD:2322961
Bos taurus DDIT4L VGNC VGNC:27949
Macaca mulatta DDIT4L VGNC VGNC:106566
Mus musculus DDIT4L MGD MGI:1920534