Il1r1 - interleukin 1 receptor type 1 Gene

Rattus norvegicus

Also known as IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha

Gene ID: 25663 | Gene type: protein coding

About Il1r1

Summary

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including interleukin-1-mediated signaling pathway; positive regulation of neuron migration; and response to odorant. Located in several cellular components, including axon; cell surface; and postsynaptic density. Part of protein-containing complex. Biomarker of pulpitis. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1r1 Products(2)

mRNA	Protein	Name
NM_001412593.1	NP_001399522.1	interleukin-1 receptor type 1 precursor
NM_001412594.1	NP_001399523.1	interleukin-1 receptor type 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	21314939	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19198660	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	20034811	RGD
involved in heat acclimation	IMP IMP: Inferred from mutant phenotype	19022353	RGD
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20967881	RGD
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	24950657	RGD
involved in response to epidermal growth factor	IEP IEP: Inferred from expression pattern	9233842	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	10375024	RGD
involved in response to nitric oxide	IEP IEP: Inferred from expression pattern	10375024	RGD
involved in response to odorant	IEP IEP: Inferred from expression pattern	23103411	RGD
involved in response to transforming growth factor beta	IEP IEP: Inferred from expression pattern	9233842	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	19732182	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21925583	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	17681838	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	21314939	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-1 receptor type 1

CD121 antigen-like family member A	interleukin 1 beta receptor type 1 short transmembrane form
interleukin 1 beta receptor type 1 soluble form	interleukin 1 bete receptor type 1 long transmembrane form
interleukin-1 receptor alpha	interleukin-1 recep

Recombinant Il1r1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74821	IL-1R1 Protein, Rat (HEK293, His-mFc)	A6INN1/NP_037255.3 (L34-K352)	≥95%
HY-P74822	IL-1R1 Protein, Rat (HEK293, His)	NP_037255.3(L34-K352)	≥95%

Related Agents

Approval

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108841	Raleukin	Antagonist	99.40%	Unkown
HY-108822	Rilonacept	Inhibitor	≥95.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1110	AF12198	Inhibitor	99.75%	Unkown
HY-RS06720	IL1R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99140	Anti-Mouse IL-1R Antibody (JAMA-147)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il1r1	NCBI	NCBI:3554
Macaca fascicularis	Il1r1	NCBI	NCBI:102146317

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