2. Gene
  3. PLAT - Plat plasminogen activator, tissue type Gene

PLAT - Plat plasminogen activator, tissue type Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as tPA; PATISS

Gene ID: 25692 | Gene type: protein coding

About PLAT

Summary

Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of ovulation; and prevention of polyspermy. Located in cytoplasm; extracellular space; and synapse. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; Factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Apr 2022]

PLAT Products(1)

mRNA Protein Name
NM_013151.3 NP_037283.2 tissue-type plasminogen activator precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
3137452 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
3102470 RGD
involved in cellular response to luteinizing hormone stimulus IEP
IEP: Inferred from expression pattern
3102470 RGD
involved in plasminogen activation IDA
IDA: Inferred from direct assay
8343497 RGD
involved in prevention of polyspermy IDA
IDA: Inferred from direct assay
1515147 RGD
involved in regulation of synaptic plasticity IEP
IEP: Inferred from expression pattern
12070304 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
3017447 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
14614217 RGD
involved in synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
15496678 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
3102470 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16555239 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16555239 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
21976424 RGD
is active in neuronal dense core vesicle IMP
IMP: Inferred from mutant phenotype
21976424 RGD
is active in perisynaptic space IDA
IDA: Inferred from direct assay
16555239 RGD
is active in perisynaptic space IMP
IMP: Inferred from mutant phenotype
16555239 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
15496678 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
16555239 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tissue-type plasminogen activator

t-PA

t-plasminogen activator

tissue plasminogen activator

tissue-type plasminogen activator-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10646 PLAT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PLAT NCBI NCBI:5327
Canis familiaris PLAT NCBI NCBI:482840
Macaca fascicularis PLAT NCBI NCBI:102145462
Mus musculus PLAT NCBI NCBI:18791
Macaca mulatta PLAT NCBI NCBI:704475