1. Gene
  2. PLAT - plasminogen activator, tissue type Gene

PLAT - plasminogen activator, tissue type Gene

Homo sapiens

Also known as TPA; T-PA

Gene ID: 5327 | Gene type: protein coding

About PLAT

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,174,718-42,207,565 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in urinary bladder (RPKM 61.1), placenta (RPKM 41.3) and 18 other tissues.

Summary

This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic Enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric Enzyme. This Enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

PLAT Products(3)

mRNA Protein Name
NM_000930.5 NP_000921.1 tissue-type plasminogen activator isoform 1 preproprotein
NM_001319189.2 NP_001306118.1 tissue-type plasminogen activator isoform 4 precursor
NM_033011.4 NP_127509.1 tissue-type plasminogen activator isoform 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
8186264 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
2503541 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
1695900 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
8186264 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of proteolysis IDA
IDA: Inferred from direct assay
1695900 GOA
involved in plasminogen activation IDA
IDA: Inferred from direct assay
12694198 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
1632457 GOA
NOT located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
1632457 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
1632457 GOA
part of serine protease inhibitor complex IPI
IPI: Inferred from physical interaction
26324706 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAT Protein Structure

fn1

fn1: Fibronectin type I domain (41 - 78)

EGF

EGF: EGF-like domain (86 - 117)

Kringle

Kringle: Kringle domain (127 - 208)

Kringle

Kringle: Kringle domain (215 - 296)

Trypsin

Trypsin: Trypsin (311 - 556)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 562 a.a.
Protein Preferred Names Protein Names

tissue-type plasminogen activator

alteplase

Recombinant PLAT Proteins

Cat. No. Product Name Accession Purity
HY-P71051 T-PA Protein, Human (HEK293, His) P00750-1 (S36-P562) ≥95%
HY-P73451 T-PA Protein, Human (HEK293) NP_000921.1 (I311-P562) ≥95%

Related Diseases

Diseases Alias
Lethal Hydranencephaly-Diaphragmatic Hernia Syndrome
Thrombophilia, Familial, Due To Decreased Release Of Tissue Plasminogen Activator

THPH9

Pulmonary Embolism

Pulmonary Artery Embolism

Pulmonary Embolus

Pulmonary Emboli

Thrombosis

Thrombosis Of Blood Vessel

Coronary Thrombosis

Coronary Artery Thrombosis

Hepatic Veno-Occlusive Disease

Veno-Occlusive Disease

Sinusoidal Obstruction Syndrome

Hepatic Venoocclusive Disease

Venoocclusive Disease

Hepatic Vein Thrombosis

Budd-Chiari Syndrome

Hepatic Vein Occlusion

Veno-Occlusive Disease Of The Liver

Venous Insufficiency

Peripheral Venous Insufficiency

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Cardiac Rupture

Myocardial Rupture

Middle Cerebral Artery Infarction

Infarction, Middle Cerebral Artery

Infarction Middle Cerebral Artery

Hemorrhage, Intracerebral

Intracerebral Hemorrhage

Hemorrhagic Stroke

ICH

Hemorrhage, Intracerebral, Susceptibility To

Stroke, Hemorrhagic

Stroke, Hemorrhagic, Susceptibility To

Brain Hemorrhage

Cardiogenic Shock

Shock Cardiogenic

Shock, Cardiogenic

Fibrinolytic Defect
Basilar Artery Occlusion
Disseminated Intravascular Coagulation

Defibrination Syndrome

Dic

Diffuse Or Disseminated Intravascular Coagulation

Fibrinolytic Purpura

Consumption Coagulopathy

Diffuse Intravascular Coagulation

Dic - [Disseminated Intravascular Coagulation]

Disseminated Intravascular Coagulopathy

Fibrinolysis Nos

Thrombolytic Purpura

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Peripheral Vascular Disease

Peripheral Arterial Disease

Arterial Occlusive Disease

Arterial Occlusive Diseases

Pad

Peripheral Vascular Diseases

Peripheral Occlusive Disease

Peripheral Arterial Diseases

Helicobacter Infections

Occlusion Precerebral Artery

Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries

Occlusion And Stenosis Of Precerebral Artery

Thrombophlebitis

Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities

Superficial Thrombophlebitis Of Leg

Thrombophlebitis Of A Superficial Leg Vein

Thrombophlebitis Of Superficial Veins Of Lower Extremity

Vitreous Detachment

Posterior Vitreous Detachment

Vitreous Syneresis

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Vertebral Artery Occlusion

Occlusion And Stenosis Of Vertebral Artery

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome

Hughes Syndrome

Familial Antiphospholipid Syndrome

Aps

Lupus Anticoagulant, Familial

Anti-Phospholipid Syndrome

Apls

Classic Apls

Classic Antiphospholipid Syndrome

Acromegaloid Facial Appearance Syndrome

Anticardiolipin Syndrome

Ischemia

Acute Coronary Syndrome

Gingivitis

Chronic Gingivitis

Acute Gingivitis

Basal Ganglia Cerebrovascular Disease
Intracranial Embolism

Cerebral Embolism

Cerebral Embolism With Cerebral Infarction

Von Willebrand'S Disease

Von Willebrand Disease

Von Willebrand Disorder

Vascular Pseudohemophilia

Hereditary Von Willebrand Disease

Vwd

Vascular Hemophilia

Von Willebrand'S-Jurgens' Disease

Von Willebrand-Jrgens Disease

Von Willebrand Factor Deficiency

Von Willebrand Factor, Deficiency

Angiohemophilia

Von Willebrand'S Factor Deficiency

Von Willebrand Diseases

Factor Viii Deficiency With Vascular Defect

Vascular Haemophilia

Willebrand Jurgen Thrombopathy

Pseudohaemophilia

Minot-Von Willebrand-Jurgen Disease

Angiohaemophilia

Angiohaemophilia A

Angiohaemophilia B

Eisenmenger Syndrome

Eisenmenger Complex

Inferior Myocardial Infarction

Inferior Wall Myocardial Infarction

Coronary Restenosis
Cerebrovascular Disease

Cerebrovascular Disorder

Cerebrovascular Accident

Cerebrovascular Disorders

Cva

Stroke

Mercury Poisoning

Mercurialism

Mercury Toxicity

Hydrargyria

Mercury Intoxication

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Cerebral Artery Occlusion
Thrombophilia Due To Thrombin Defect

Venous Thromboembolism

Venous Thrombosis

Thrombophilia Due To Factor 2 Defect

Thromboembolism

THPH1

Thromboembolism, Susceptibility To

Venous Thromboembolism, Susceptibility To

Venous Thrombosis, Protection Against

Prothrombin-Related Thrombophilia

Hyperprothrombinemia

Venous Thrombosis, Susceptibility To

Thrombophilia 1 Due To Thrombin Defect

F2-Related Thrombophilia

Factor Ii-Related Thrombophilia

Prothrombin 20210g>A Thrombophilia

Prothrombin G20210a Thrombophilia

Prothrombin Thrombophilia

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Atrial Fibrillation

A-Fib

Fibrillation, Atrial

Af - [Atrial Fibrillation]

Rapid Atrial Fibrillation

A Fib - [Atrial Fibrillation]

Central Serous Chorioretinopathy

Central Serous Chorioretinopathy After Bone Marrow Transplantation

Central Serous Choroidopathy

Cscr

Central Serous Retinopathy

Central Serous Choroidoretinopathy

Angina Pectoris

Prinzmetal'S Variant Angina

Angina

Prinzmetal Angina

Variant Angina

Angina Inversa

Prinzmetal'S Angina

Coronary Artery Vasospasm

Angina Pectoris, Variant

Variant Angina Pectoris

Vasospastic Angina

Angor Pectoris

Anginal Syndrome

Ischaemic Chest Pain

Angina Pectoris Syndrome

Angina Syndrome

Cardiac Angina Syndrome

Ap - [Angina Pectoris]

Angina Nos

Ap - [Angina Pectoris] Syndrome

Ischaemic Heart Disease With Angina

Heart Angina

Chest Angina

Angina Attack

Anginal Cardiopathy

Coronary Pain Nos

Carotid Artery Occlusion

Occlusion And Stenosis Of Carotid Artery

Hyperhomocysteinemia
Central Retinal Vein Occlusion

Crvo

Post-Thrombotic Syndrome

Postphlebitic Syndrome

Postthrombotic Syndrome

Postphlebetic Syndrome With Inflammation

Postphlebetic Syndrome With Ulcer

Postphlebetic Syndrome With Ulcer And Inflammation

Venous Stress Disorder

Central Retinal Artery Occlusion
Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction

Afibrinogenemia, Congenital

Congenital Afibrinogenemia

Afibrinogenemia

Factor I Deficiency

Familial Afibrinogenemia

Hypofibrinogenemia, Congenital

Fibrinogen Deficiency

Afibrinogenemia Congenital

CAFBN

Congenital Hypofibrinogenemia

Hypofibrinogenemia

Complement Factor I Deficiency

Endocarditis
Thrombophilia

Hypercoagulability State

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies

FENIB

Encephalopathy, Familial, With Collins Bodies

Familial Dementia With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Collins Bodies

Plasminogen Deficiency, Type I

Hypoplasminogenemia

Dysplasminogenemia

Plasminogen Deficiency Type I

Congenital Plasminogen Deficiency

Ligneous Conjunctivitis

Type 1 Plasminogen Deficiency

Plasminogen Deficiency Type 1

Plasminogen Deficiency

PLGD

Plasminogen Deficiency Type Ii

Deficiency, Plasminogen, Type I

Speech And Communication Disorders

Language Disorder

Communication Disorder

Language Disorders

Communication Disorders

Speech Language Disorder

Speech-Language Disorder

Communication Impairment

Speech And Language Disorder

Anterolateral Myocardial Infarction

Anterior Wall Myocardial Infarction

Anterior Myocardial Infarction

Hemorrhagic Disease

Hemorrhagic Disorders

Hemorrhagic Diathesis

Hemorrhagic Diseases

Bleeding Tendency

Acquired Coagulation Factor Inhibitor Disorder

Acquired Inhibitor Of Coagulation

Antithrombinaemia

Antithromboplastinogenaemia

Circulating Anticoagulant Disorder

Haemorrhagic Disorder Due To Antithrombinaemia

Haemorrhagic Disorder Due To Excess Administered Heparin

Antithromboplastinaemia

Haemorrhagic Disorder Due To Hyperheparinemia

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage

Familial Berry Aneurysm

Familial Intracranial Saccular Aneurysm

Saccular Cerebral Aneurysm

Aneurysm, Intracranial Berry

Aneurysmal Subarachnoid Hemorrhage

Aneurysm, Intracranial Berry, 1

Varicose Veins

Varices

Varix

Venous Ectasia

Venous Varices

Varicosity

Conversion Disorder

Conversion Hysteria Or Reaction

Conversion Hysterical Neurosis

Hysterical Neurosis, Conversion Type

Fnd

Functional Movement Disorder

Functional Neurological Disorder

Dissociative Disorder

Pneumoconiosis

Pneumoconioses

Silicosis Nos

Complicated Silicosis

Fibrosis Of Lung With Silicosis

Nodular Silicosis

Pneumoconiosis Due To Silica

Silicotic Fibrosis Of Lung

Simple Silicosis

Silicatosis

Silicotic Lung Fibrosis

Pneumoconiosis Due To Talc

Pulmonary Talcosis

Talc Lung Disease

Talc Pneumoconiosis

Talc Workers' Pneumoconiosis

Talcosis

Fibrosis Of Lung Due To Talc

Asbestos Pneumoconiosis

Amianthosis

Asbestosis

Lung Fibrosis With Asbestosis

Pulmonary Asbestosis

Platelet Aggregation, Spontaneous
Dysfibrinogenemia, Congenital

Dysfibrinogenemia

Hypodysfibrinogenemia

Familial Dysfibrinogenemia

Familial Hypodysfibrinogenemia

Hypodysfibrinogenemia, Congenital

Dysfibrinogenemia, Familial

Congenital Dysfibrinogenemia

DYSFIBRIN

Deafness, Autosomal Recessive 77

DFNB77

Autosomal Recessive Nonsyndromic Deafness 77

Autosomal Recessive Deafness 77

Deafness, Autosomal Recessive, 77

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 77

Deafness, Autosomal Recessive, Type 77

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Posterior Myocardial Infarction
Thoracic Outlet Syndrome

Tos

Tos - Thoracic Outlet Syndrome

Thoracic Outlet Syndromes

Thoracic Outlet Compression Syndrome

Hellp Syndrome

Hemolysis, Elevated Liver Enzymes, Lowered Platelets

Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy

Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome

Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet]

Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome

Carotid Artery Disease

Carotid Artery Diseases

Disorder Of Carotid Artery

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Nonbacterial Thrombotic Endocarditis

Non-Bacterial Thrombotic Endocarditis

Marantic Endocarditis

Non-Infective Endocarditis

Femoral Neuropathy

Femoral Nerve Dysfunction

Femoral Nerve Lesions

Acute Cor Pulmonale
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Raynaud Disease

Raynaud'S Disease

Raynaud Phenomenon

Raynaud'S Syndrome

Raynaud'S

Cold Fingers, Hereditary

Raynaud'S Phenomenon

Raynaud'S Disease/Phenomenon

Raynauds Syndrome

Raynauds Phenomenon

Secondary Raynaud'S Phenomenon

Raynaud Syndrome

Acute Pulmonary Heart Disease
Carotid Artery Thrombosis
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Obstructive Hydrocephalus
Postaxial Acrofacial Dysostosis

Miller Syndrome

POADS

Genee-Wiedemann Syndrome

Postaxial Acrodysostosis

Genee-Wiedemann Acrofacial Dysostosis

Acrofacial Dysostosis, Genee-Wiedmann Type

Mandibulfacial Dysostosis With Postaxial Limb Anomalies

Gwafd

Poads Syndrome

Postaxial Acrofacial Dysostosis Syndrome

Wildervanck-Smith Syndrome

Acrofacial Dysostosis, Genee-Wiedemann Type

Mandibulofacial Dysostosis With Postaxial Limb Anomalies

Genée-Wiedemann Syndrome

Chromosome 11p Deletion Syndrome

Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos

Cardiac Tamponade

Pericardial Tamponade

Rose'S Tamponade

Atherosclerosis Susceptibility

Atherosclerosis

Atherosclerosis, Susceptibility To

ATHS

Atherogenic Lipoprotein Phenotype

Alp

Arteriosclerosis

Hemopericardium

Haemopericardium

Pericardial Effusion

Haematopericardium

Pneumohemopericardium

Pericardium Haemorrhage

Haemorrhagic Pericarditis

Intracranial Thrombosis

Cerebral Thrombosis

Thrombosis Of Cerebral Veins

Cerebral Arterial Thrombosis

Tuberculous Empyema

Empyema, Tuberculous

Empyema Tuberculous

Transient Cerebral Ischemia

Transient Ischemic Attack

Transient Ischemic Attacks

Tia

Tia - Transient Ischaemic Attack

Transient Cerebral Ischaemia

Ischemic Attack, Transient

Intermittent Cerebral Ischemia

Tia - [Transient Ischaemic Attack]

Intermittent Cerebral Ischaemia

Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Pleural Empyema

Empyema

Pyothorax

Empyema, Pleural

Abscess Of Pleural Cavity

Abscess Of Thorax

Empyema Of Pleura

Empyema Of Pleura Without Fistula

Empyema With Fistula

Empyema With No Fistula

Empyema With Pleural Fistula

Empyema Without Mention Of Fistula

Empyema, Chest

Lung Empyema

Pleural Empyema With Fistula

Pleural Empyema With No Fistula

Purulent Pleurisy

Purulent Pleuritis

Thorax Abscess

Pyopneumothorax

Tibial Nerve Palsy
Transient Global Amnesia

Amnesia, Transient Global

Vein Disease

Disorder Of Vein

Aphasia
Heart Conduction Disease

Conduction Disorder Of The Heart

Heart Rhythm Disease

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

Hemiplegia

Infantile Hemiplegia

Postnatal Infantile Hemiplegia

Hemiplegia, Infantile

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect

Mitral Valve Stenosis

Mitral Stenosis

Rheumatic Mitral Stenosis

Ms - [Mitral Stenosis]

Mitral Valvular Stricture

Mitral Valve Stricture

Mitral Stricture

Chronic Mitral Stenosis

Mitral Obstruction

Mitral Valve Obstruction

Mitral Stenosis With Incompetence

Mitral Stenosis With Regurgitation

Rheumatic Mitral Insufficiency With Obstruction

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Cerebral Arterial Disease

Cerebral Arterial Diseases

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Tricuspid Valve Insufficiency

Tricuspid Regurgitation

Tricuspid Valve Regurgitation

Tricuspid Incompetence

Tr - [Tricuspid Regurgitation]

Tricuspid Valve Incompetency

Tricuspid Valve Annular Incompetency

Facial Paralysis

Facial Palsy

Bell Palsy

Facial Nerve Disease

Facial Nerve Disorder

Facial Nerve Diseases

Neuropathy Of Facial Nerve

Disorders Of 7th Cranial Nerve

Disorders Of The Seventh Cranial Nerve

Tricuspid Valve Disease

Rheumatic Tricuspid Valve Disease

Disease Of Tricuspid Valve

Rh. Tricuspid Valve Disease

Rheumatic Disease Of Tricuspid Valve

Tricuspid Disease

Tricuspid Valve Disorder

Aspiration Pneumonia

Pneumonia, Aspiration

Pneumonia Aspiration

Aspiration Pneumonitis

Moyamoya Disease 1

Moyamoya Disease

Spontaneous Occlusion Of The Circle Of Willis

Mymy

Progressive Intracranial Arterial Occlusion

Moyamoya Syndrome

MYMY1

Cerebrovascular Moyamoya Disease

Moya-Moya Disease

Progressive Intracranial Occlusive Arteropathy

Idiopathic Moyamoya Disease

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Atrial Heart Septal Defect

Atrial Septal Defect

Atrial Septal Defects

Atrioseptal Defect

Auricular Septal Defect

Congenital Atrial Septal Defect

Interatrial Septal Defect

Interauricular Septal Defect

Heart Septal Defects, Atrial

Septal Defect, Atrial

Blood Coagulation Disease

Blood Coagulation Disorders

Coagulation Protein Disease

Inherited Blood Coagulation Disease

Postpartum Coagulation Defect

Postpartum Coagulation Defect With Delivery

Coagulation Protein Disorders

Puerperal Coagulopathy

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Diabetes Mellitus

Diabetes

Arteriovenous Malformation

Arteriovenous Malformations

Arteriovenous Hemangioma

Cirsoid Aneurysm

Racemose Aneurysm

Racemose Angioma

Racemose Hemangioma

Congenital Arteriovenous Malformation

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PLAT VGNC VGNC:32974
Felis catus PLAT VGNC VGNC:68891
Rattus norvegicus PLAT RGD RGD:3342
Mus musculus PLAT MGD MGI:97610
Macaca mulatta PLAT VGNC VGNC:76161
Canis familiaris PLAT NCBI NCBI:482840
Macaca fascicularis PLAT NCBI NCBI:102145462
Others PLAT NCBI