Ctsl - cathepsin L Gene

Rattus norvegicus

Also known as CatL; CATHL; Ctsl1

Gene ID: 25697 | Gene type: protein coding

About Ctsl

Primary_assembly 17: 764,309-770,548 forward strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 711 orthologues, 27 paralogues and is associated with 26 phenotypes. Biased expression in Kidney (RPKM 13282.8), Liver (RPKM 4121.4) and 6 other tissues.

Summary

Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; reproductive structure development; and response to odorant. Located in several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (Cathepsin V). [provided by Alliance of Genome Resources, Apr 2022]

Ctsl Products(1)

mRNA	Protein	Name
NM_013156.2	NP_037288.1	procathepsin L preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	8702598	RGD
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	12788072	RGD
enables kininogen binding	IPI IPI: Inferred from physical interaction	3356189	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	8702598	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	2470410	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Sertoli cell differentiation	IEP IEP: Inferred from expression pattern	15647457	RGD
involved in autophagic cell death	IEP IEP: Inferred from expression pattern	16176344	RGD
involved in cellular response to starvation	IEP IEP: Inferred from expression pattern	16176344	RGD
involved in decidualization	IEP IEP: Inferred from expression pattern	15644143	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	16135663	RGD
involved in nerve development	IEP IEP: Inferred from expression pattern	15686940	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	11788364	RGD
involved in proteolysis	IDA IDA: Inferred from direct assay	12788072	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	15705658	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	9877467	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	14563703	RGD
involved in response to odorant	IEP IEP: Inferred from expression pattern	23103411	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18465118	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	9876020	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	15761664	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19284293	RGD
located in microvillus	IDA IDA: Inferred from direct assay	15085256	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16176344	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	18410501	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsl Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

procathepsin L

CP-2	MEP
cathepsin L1	cyclic protein 2
major excreted protein

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137978A	Ezurpimtrostat hydrochloride	Inhibitor	99.29%	Phase 2
HY-137978	Ezurpimtrostat	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128140	Z-FY-CHO	Inhibitor	96.18%	Unkown
HY-119293	K777		99.77%	Unkown
HY-RS03340	CTSL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119293A	K777 tosylate		/	Unkown
HY-157477	SARS-CoV-2 3CLpro-IN-22	Inhibitor	/	Unkown
HY-158022	CTSL/CAPN1-IN-1	Inhibitor	/	Unkown
HY-161342	CTSL/CAPN1-IN-2	Inhibitor	/	Unkown
HY-RS03341	Ctsl Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03342	Ctsl Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163029	CTSL/B-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsl	NCBI	NCBI:1514
Mus musculus	Ctsl	NCBI	NCBI:13039

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