2. Immunology/Inflammation MAPK/ERK Pathway Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. Interleukin Related p38 MAPK STAT Cathepsin JAK
  4. Dual Cathepsin L/JAK-IN-1

Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI).

For research use only. We do not sell to patients.

Dual Cathepsin L/JAK-IN-1 Chemical Structure

Dual Cathepsin L/JAK-IN-1 Chemical Structure

CAS No. : 2450279-41-9

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Dual Cathepsin L/JAK-IN-1 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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STAT3 STAT5 STAT6 STAT1

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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JAK1 JAK2 JAK3 Tyk2 JAK

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Description

Dual Cathepsin L/JAK-IN-1 (Compound A8) is a dual inhibitor of Cathepsin L (CTSL) and JAK, with IC50 values of 0.68 μM, 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for CTSL, JAK1/2/3, and TYK2, respectively. Dual Cathepsin L/JAK-IN-1 effectively blocks the activation of the MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. Dual Cathepsin L/JAK-IN-1 can be used in research on acute lung injury (ALI)[1].

IC50 & Target[1]

cathepsin L

0.68 μM (IC50)

JAK1

337.1 nM (IC50)

JAK2

5.251 nM (IC50)

JAK3

27.29 nM (IC50)

Tyk2

172.6 nM (IC50)

Molecular Weight

351.83

Formula

C19H18ClN5
CAS No.
SMILES

CN1C=C(C2=CC=CC=C21)C3=CC=NC(NC4=CC=CC(N)=C4)=N3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dual Cathepsin L/JAK-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dual Cathepsin L/JAK-IN-12450279-41-9Interleukin Relatedp38 MAPKSTATCathepsinJAKILJanus kinaseAcute lung injury (ALI)HBE Cellsraw264.7 cellsInflammationInhibitorinhibitorinhibit

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