ZNF683 - zinc finger protein 683 Gene

Homo sapiens

Also known as Hobit

Gene ID: 257101 | Gene type: protein coding

About ZNF683

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,361,634-26,374,518 (from NCBI)

This gene has 9 transcripts (splice variants), 56 orthologues and 28 paralogues. Biased expression in testis (RPKM 20.6), salivary gland (RPKM 1.7) and 1 other tissue.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in T cell receptor signaling pathway; cellular response to ionomycin; and regulation of gene expression. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF683 Products(3)

mRNA	Protein	Name
NM_001114759.3	NP_001108231.1	tissue-resident T-cell transcription regulator protein ZNF683 isoform 1
NM_001307925.1	NP_001294854.1	tissue-resident T-cell transcription regulator protein ZNF683 isoform 2
NM_173574.3	NP_775845.2	tissue-resident T-cell transcription regulator protein ZNF683 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26179882	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	26179882	GOA
involved in cellular response to ionomycin	IDA IDA: Inferred from direct assay	26179882	GOA
NOT involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26179882	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26179882	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	26179882	GOA
NOT involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	26179882	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	26179882	GOA
NOT involved in regulation of type II interferon production	IDA IDA: Inferred from direct assay	26179882	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF683 Protein Structure

zf-H2C2_2

0
100
200
300
400
524 a.a.

Protein Preferred Names

Protein Names

tissue-resident T-cell transcription regulator protein ZNF683

homolog of Blimp-1 in T cells

ZNF683 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF683	Q8IZ20	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	ZNF683	Q8IZ20	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	ZNF683	Q8IZ20	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	32296183
Intra	ZNF683	Q8IZ20	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	ZNF683	Q8IZ20	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ZNF683	Q8IZ20	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16164	ZNF683 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZNF683	VGNC	VGNC:80414
Bos taurus	ZNF683	VGNC	VGNC:37327
Canis familiaris	ZNF683	VGNC	VGNC:48794
Mus musculus	ZNF683	MGD	MGI:3650254
Macaca mulatta	ZNF683	VGNC	VGNC:79718
Rattus norvegicus	ZNF683	RGD	RGD:2323855

Name
Email *

	Sorry, but the email address you supplied was invalid.