1. Gene
  2. Apoe - apolipoprotein E Gene

Apoe - apolipoprotein E Gene

Rattus norvegicus

Also known as APOEA

Gene ID: 25728 | Gene type: protein coding

About Apoe

Summary

Enables several functions, including amyloid-beta binding activity; hydroxyapatite binding activity; and phospholipid binding activity. Involved in several processes, including cellular response to alcohol; neurogenesis; and regulation of lipid metabolic process. Located in several cellular components, including late endosome; neuronal cell body; and nuclear envelope. Is extrinsic component of external side of plasma membrane. Part of several cellular components, including discoidal high-density lipoprotein particle; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Colocalizes with early endosome and microtubule. Used to study artery disease (multiple); familial hyperlipidemia; fatty liver disease (multiple); glomerulosclerosis; and middle cerebral artery infarction. Biomarker of several diseases, including glomerulonephritis (multiple); hyperhomocysteinemia; hypertension; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract Cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human apoE (Apolipoprotein E). [provided by Alliance of Genome Resources, Apr 2022]

Apoe Products(5)

mRNA Protein Name
NM_001270681.1 NP_001257610.1 apolipoprotein E precursor
NM_001270682.1 NP_001257611.1 apolipoprotein E precursor
NM_001270683.1 NP_001257612.1 apolipoprotein E precursor
NM_001270684.1 NP_001257613.1 apolipoprotein E precursor
NM_138828.3 NP_620183.2 apolipoprotein E precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amyloid-beta binding IDA
IDA: Inferred from direct assay
22138302 RGD
enables hydroxyapatite binding IDA
IDA: Inferred from direct assay
21839718 RGD
enables lipid transporter activity IDA
IDA: Inferred from direct assay
2492020 RGD
enables phospholipid binding IDA
IDA: Inferred from direct assay
2492020 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
17889837 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
21169230 RGD
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
17478430 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
19713443 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
22171672 RGD
involved in lipid transport IDA
IDA: Inferred from direct assay
2492020 RGD
involved in lipoprotein metabolic process IDA
IDA: Inferred from direct assay
2492020 RGD
involved in negative regulation of cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
9225228 RGD
involved in oligodendrocyte differentiation IEP
IEP: Inferred from expression pattern
21972082 RGD
involved in peripheral nervous system axon regeneration IEP
IEP: Inferred from expression pattern
2120218 RGD
involved in positive regulation of axon extension IDA
IDA: Inferred from direct assay
21040802 RGD
involved in regulation of triglyceride metabolic process IDA
IDA: Inferred from direct assay
9225228 RGD
involved in response to D-galactosamine IEP
IEP: Inferred from expression pattern
6631239 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
11839466 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
22691999 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
21907828 RGD
involved in response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
12934668 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
1883846 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
2493483 RGD
part of chylomicron IDA
IDA: Inferred from direct assay
6631239 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8875469 RGD
part of discoidal high-density lipoprotein particle IDA
IDA: Inferred from direct assay
2493483 RGD
located in early endosome IDA
IDA: Inferred from direct assay
19809892 RGD
located in endosome IDA
IDA: Inferred from direct assay
2493483 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16947119 RGD
located in extrinsic component of external side of plasma membrane IDA
IDA: Inferred from direct assay
7616121 RGD
part of high-density lipoprotein particle IDA
IDA: Inferred from direct assay
1906919 RGD
part of intermediate-density lipoprotein particle IDA
IDA: Inferred from direct assay
9211985 RGD
located in late endosome IDA
IDA: Inferred from direct assay
7806565 RGD
part of low-density lipoprotein particle IDA
IDA: Inferred from direct assay
7119568 RGD
located in microtubule IDA
IDA: Inferred from direct assay
19809892 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8875469 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
2493483 RGD
part of very-low-density lipoprotein particle IDA
IDA: Inferred from direct assay
9211985 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apolipoprotein E

apo-E

Recombinant Apoe Proteins

Cat. No. Product Name Accession Purity
HY-P701096 Apolipoprotein E/APOE Protein, Rat (His) P02650 (E19-Q312) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Apoe NCBI NCBI:348
Mus musculus Apoe NCBI NCBI:11816
Leporidae Apoe NCBI