Apoe - apolipoprotein E Gene

Mus musculus

Also known as Apo-E

Gene ID: 11816 | Gene type: protein coding

About Apoe

Chromosome 7: 19,430,034-19,433,113 reverse strand.GRCm39:CM001000.3

This gene has 11 transcripts (splice variants), 222 orthologues, 3 paralogues and is associated with 190 phenotypes. Biased expression in liver adult (RPKM 95.), liver E18 (RPKM 4149.1) and 1 other tissues.

Summary

This gene encodes a member of the Apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of Cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related Apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]

Apoe Products(4)

mRNA	Protein	Name
NM_001305844.1	NP_001292773.1	apolipoprotein E precursor
NM_001305843.1	NP_001292772.1	apolipoprotein E precursor
NM_001305819.1	NP_001292748.1	apolipoprotein E precursor
NM_009696.4	NP_033826.2	apolipoprotein E precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholesterol transfer activity	IDA IDA: Inferred from direct assay	15269218	MGI
enables heparan sulfate proteoglycan binding	IDA IDA: Inferred from direct assay	23676495	MGI
enables lipoprotein particle binding	IDA IDA: Inferred from direct assay	11553788	MGI
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IMP IMP: Inferred from mutant phenotype	15654758	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23055941	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within artery morphogenesis	IGI IGI: Inferred from genetic interaction	16230502	MGI
NOT acts upstream of or within axon regeneration	IGI IGI: Inferred from genetic interaction	7798939	MGI
acts upstream of or within cholesterol catabolic process	IMP IMP: Inferred from mutant phenotype	9826706	MGI
acts upstream of or within cholesterol efflux	IDA IDA: Inferred from direct assay	15269218	MGI
acts upstream of or within cholesterol efflux	IMP IMP: Inferred from mutant phenotype	11551841	MGI
acts upstream of or within cholesterol homeostasis	IGI IGI: Inferred from genetic interaction	11120757	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	1423598	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	23741427	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	1423598	MGI
acts upstream of or within circulatory system development	IMP IMP: Inferred from mutant phenotype	19816508	MGI
acts upstream of or within negative effect gene expression	IGI IGI: Inferred from genetic interaction	26397958	MGI
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	8185566	MGI
acts upstream of or within lipid homeostasis	IMP IMP: Inferred from mutant phenotype	17720994	MGI
acts upstream of or within lipid metabolic process	IGI IGI: Inferred from genetic interaction	11120757	MGI
involved in lipid transport involved in lipid storage	IMP IMP: Inferred from mutant phenotype	23741427	MGI
acts upstream of or within lipoprotein biosynthetic process	IGI IGI: Inferred from genetic interaction	14595002	MGI
acts upstream of or within lipoprotein catabolic process	IMP IMP: Inferred from mutant phenotype	17720994	MGI
acts upstream of or within lipoprotein metabolic process	IGI IGI: Inferred from genetic interaction	11120757	MGI
acts upstream of or within lipoprotein metabolic process	IMP IMP: Inferred from mutant phenotype	9788969	MGI
involved in low-density lipoprotein particle remodeling	IMP IMP: Inferred from mutant phenotype	15654758	MGI
acts upstream of or within maintenance of location in cell	IMP IMP: Inferred from mutant phenotype	17720994	MGI
involved in melanosome organization	IMP IMP: Inferred from mutant phenotype	26387950	MGI
involved in negative regulation of amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	14741101	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18377911	MGI
involved in negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	21784977	MGI
acts upstream of negative regulation of smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	18382765	MGI
acts upstream of or within negative regulation of triglyceride metabolic process	IGI IGI: Inferred from genetic interaction	9240444	MGI
involved in positive regulation of CoA-transferase activity	IMP IMP: Inferred from mutant phenotype	15654758	MGI
involved in positive regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	14741101	MGI
involved in positive regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	31902528	MGI
involved in positive regulation of cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	15654758	MGI
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23845000	MGI
NOT acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	9325076	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	29336888	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17720994	MGI
involved in regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	29336888	MGI
involved in regulation of plasma lipoprotein particle levels	IMP IMP: Inferred from mutant phenotype	23741427	MGI
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	27683909	MGI
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	27683909	MGI
acts upstream of or within response to dietary excess	IMP IMP: Inferred from mutant phenotype	17720994	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	8773783	MGI
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	23676495	MGI
involved in triglyceride-rich lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	23676495	MGI
acts upstream of or within vasodilation	IMP IMP: Inferred from mutant phenotype	9826706	MGI
involved in very-low-density lipoprotein particle remodeling	IMP IMP: Inferred from mutant phenotype	15654758	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7798939	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27683909	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27683909	MGI
part of low-density lipoprotein particle	IDA IDA: Inferred from direct assay	15654758	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Apoe Protein Structure

Apolipoprotein

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

apolipoprotein E

Recombinant Apoe Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7532	Apolipoprotein E/APOE Protein, Mouse (HEK293, His)	P08226 (E19-Q311)	≥95%
HY-P78239	Apolipoprotein E/APOE Protein, Mouse (HEK293, Fc)	P08226 (E19-Q311)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103076	EZ-482		97.11%	Unkown
HY-112798	PH-002	Inhibitor	98.78%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apoe	NCBI	NCBI:348
Leporidae	Apoe	NCBI
Rattus norvegicus	Apoe	NCBI	NCBI:25728

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