CIZ1 - CDKN1A interacting zinc finger protein 1 Gene

Homo sapiens

Also known as NP94; LSFR1; ZNF356

Gene ID: 25792 | Gene type: protein coding

About CIZ1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,166,065-128,204,222 (from NCBI)

This gene has 28 transcripts (splice variants), 243 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 30.0), testis (RPKM 29.2) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CIZ1 Products(7)

mRNA	Protein	Name
NM_001131015.2	NP_001124487.1	cip1-interacting zinc finger protein isoform 2
NM_001131016.2	NP_001124488.1	cip1-interacting zinc finger protein isoform 1
NM_001131017.2	NP_001124489.1	cip1-interacting zinc finger protein isoform 3
NM_001131018.2	NP_001124490.1	cip1-interacting zinc finger protein isoform 4
NM_001257975.2	NP_001244904.1	cip1-interacting zinc finger protein isoform 5
NM_001257976.2	NP_001244905.1	cip1-interacting zinc finger protein isoform 6
NM_012127.3	NP_036259.2	cip1-interacting zinc finger protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18654987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	23145069	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIZ1 Protein Structure

zf-C2H2_jaz

0
200
400
600
800
898 a.a.

Protein Preferred Names

Protein Names

cip1-interacting zinc finger protein

nuclear protein NP94

CIZ1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIZ1	Q9ULV3	SH3BP4	Homo sapiens	Q9P0V3	Y2H	18654987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 31

DEE31	Epileptic Encephalopathy, Early Infantile, 31
Eiee31	Developmental And Epileptic Encephalopathy, 31
Early Infantile Epileptic Encephalopathy 31	Encephalopathy, Epileptic, Early Infantile, Type 31

Cervical Dystonia

Spasmodic Torticollis

Dystonia 23

DYT23	Adult-Onset Cervical Dystonia, Dyt23 Type
Dystonia, Type 23

Motor Stereotypies

Motor Stereotypy

Stereotypic Movement Disorder

Stereotypy Habit Disorder	Stereotyped Repetitive Movements
Stereotyped Disorder	Stereotypes Nos
Stereotype Habit Disorder

Focal Dystonia

Dystonia, Focal, Task-Specific

Torsion Dystonia 2

Dystonia 2, Torsion, Autosomal Recessive

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

Hypotonia

Dystonia 25

DYT25	Dystonia-25
Dystonia, Type 25

Torsion Dystonia 4

Dystonia 1, Torsion, Autosomal Dominant

Dystonia Musculorum Deformans 1	Dystonia Musculorum Deformans
DYT1	Early-Onset Torsion Dystonia
Eotd	Dystonia-1, Torsion
Torsion Dystonia 1	Autosomal Dominant Torsion Dystonia 1
Dystonia-1	Oppenheim'S Dystonia
Oppenheim-Ziehen Disease	Early Onset Torsion Dystonia
Dystonia 3, Torsion, X-Linked

Torticollis

Contracture Of Neck	Wry Neck
Wry Neck/Torticollis

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Segmental Dystonia

Dystonia 6, Torsion

DYT6	Torsion Dystonia 6
Dystonia 6	Idiopathic Torsion Dystonia Of Mixed Type
Primary Dystonia, Dyt6 Type	Torsion Dystonia, Adult-Onset, Mixed Type
Dyt-Thap1	Adolescent-Onset Dystonia Of Mixed Type
Torsion Dystonia Adult Onset Mixed Type	Dyt6 Dystonia
Thap1 Dystonia	Generalized Cervical And Upper-Limb-Onset Dystonia
Adult-Onset Torsion Dystonia Mixed Type	Autosomal Dominant Torsion Dystonia 6
Dystonia-6	Torsion Dystonia Type 6
Dystonia, Type 6, Torsion

Dystonia 27

DYT27	Primary Dystonia, Dyt27 Type
Dystonia, Type 27

Multifocal Dystonia

Spasmodic Dystonia

Laryngeal Dystonia

Jaw Cancer

Jaw Neoplasms	Jaw Neoplasm
Neoplasm Of Jaw	Cancer Of Jaw

Leukodystrophy, Hypomyelinating, 6

Habc	Hypomyelinating Leukodystrophy 6
HLD6	H-Abc
Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum	Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum
Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum	HLD
Leukodystrophy, Hypomyelinating, Type 6

Hereditary Lymphedema Ii

Meige Syndrome	Meige Disease
Meige Lymphedema	Hereditary Lymphedema Type Ii
Lymphedema Hereditary Type 2	Lymphedema Praecox
Lymphedema, Hereditary, Ii	Blepharospasm-Oromandibular Dystonia Syndrome
Meige Dystonia	Meige'S Syndrome
Late-Onset Lymphedema	Lmph2
Lymphedema Preacox	Lymphedema, Late-Onset
Blepharospasm - Oromandibular Dystonia	Blepharospasm-Oromandibular Dystonia
Brueghel Syndrome	Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome
Oral Facial Dystonia	Segmental Cranial Dystonia
Meigs Syndrome

Blepharospasm

Oromandibular Dystonia

Hemidystonia

Lymphatic Malformation 5

Meige Syndrome	Meige Disease
Meige Lymphedema	Lymphedema Praecox
Lymphedema, Late-Onset	Late-Onset Lymphedema
LMPH2	Meigs Syndrome
LMPHM5	Lymphedema, Hereditary, Ii, Formerly
Lmph2, Formerly	Hereditary Lymphedema Ii
Demons-Meigs Syndrome	Hereditary Lymphedema Type Ii
Lymphedema, Hereditary, 2	Lymphedema, Hereditary, Ii
Meige'S Disease

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia	Ahc
Alternating Hemiplegia Syndrome	Hemiplegia, Alternating, Of Childhood
Hemiplegia, Crossed

Focal Hand Dystonia

Organic Writer'S Cramp

Dystonia, Focal, Task-Specific

Dystonia 12

DYT12	Rdp
Generalized Dystonia	Dystonia-12
Rapid-Onset Dystonia-Parkinsonism	Familial Dystonia
Dystonia Musculorum Deformans	Dystonic Disorders
Idiopathic Familial Dystonia	Dystonia-Parkinsonism, Rapid-Onset
Fragments Of Torsion Dystonia	Dyt-Atp1a3
Rapid-Onset Dystonia Parkinsonism	Rodp
Dystonia, Type 12	Dystonia 3, Torsion, X-Linked
Idiopathic Non-Familial Dystonia	Symptomatic Torsion Dystonia
Dystonia Disorders

Dystonia 11, Myoclonic

Myoclonic Dystonia	Myoclonus-Dystonia Syndrome
DYT11	Myoclonic Dystonia 11
Alcohol-Responsive Dystonia	Myoclonus, Hereditary Essential
Dystonia-11, Myoclonic	Myoclonus-Dystonia
Dystonia 11	Hereditary Essential Myoclonus
Dystonia, Alcohol-Responsive	Dyt-Sgce
Dystonia, Alcohol Responsive	Dystonia-11
Dystonia, Myoclonic	Dystonia, Myoclonic, Type 11

Movement Disease

Movement Disorders

Movement Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02731	CIZ1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CIZ1	VGNC	VGNC:27379
Macaca mulatta	CIZ1	VGNC	VGNC:71184
Rattus norvegicus	CIZ1	RGD	RGD:1305336
Mus musculus	CIZ1	MGD	MGI:1920234
Felis catus	CIZ1	VGNC	VGNC:60911
Canis familiaris	CIZ1	VGNC	VGNC:39285