2. Gene
  3. SPDEF - SAM pointed domain containing ETS transcription factor Gene

SPDEF - SAM pointed domain containing ETS transcription factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PDEF; bA375E1.3

Gene ID: 25803 | Gene type: protein coding

About SPDEF

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,537,802-34,556,329 (from NCBI)

This gene has 2 transcripts (splice variants), 245 orthologues and 28 paralogues. Biased expression in prostate (RPKM 50.1), salivary gland (RPKM 10.8) and 5 other tissues.

Summary

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than Other cancer-associated molecules, making it a more suitable target for developing specific Cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SPDEF Products(2)

mRNA Protein Name
NM_001252294.2 NP_001239223.1 SAM pointed domain-containing Ets transcription factor isoform 2
NM_012391.3 NP_036523.1 SAM pointed domain-containing Ets transcription factor isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21656828 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21656828 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPDEF Protein Structure

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (132 - 212)

Ets

Ets: Ets-domain (249 - 333)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

SAM pointed domain-containing Ets transcription factor

prostate epithelium-specific Ets transcription factor

SPDEF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPDEF O95238 CEP57 Homo sapiens Q86XR8-3
Validated Y2H
32296183
Intra
SPDEF O95238 SNX20 Homo sapiens Q7Z614-3
Validated Y2H
32296183
Intra
SPDEF O95238 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra
SPDEF O95238 COX5A Homo sapiens P20674
Validated Y2H
32296183
Intra
SPDEF O95238 FAM161B Homo sapiens Q96MY7
Validated Y2H
32296183
Intra
SPDEF O95238 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
SPDEF O95238 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Allergic Cutaneous Vasculitis

Allergic Cutaneous Angiitis

Autoimmune Hypersensitivity Angiitis

Vasculitis, Leukocytoclastic, Cutaneous
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Ascending Colon Cancer

Malignant Tumor Of Ascending Colon

Ca Ascending Colon

Malignant Neoplasm Of Right Colon

Malignant Neoplasm Of Ascending Colon
Lung Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Lung
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0603 Fluticasone Agonist / Unkown
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13652 SPDEF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SPDEF VGNC VGNC:65628
Macaca mulatta SPDEF VGNC VGNC:104430
Canis familiaris SPDEF VGNC VGNC:46726
Rattus norvegicus SPDEF RGD RGD:1594842
Mus musculus SPDEF MGD MGI:1353422
Bos taurus SPDEF VGNC VGNC:35198