DPCD - deleted in primary ciliary dyskinesia homolog (mouse) Gene

Homo sapiens

Gene ID: 25911 | Gene type: protein coding

About DPCD

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,588,321-101,609,662 (from NCBI)

This gene has 6 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 51.1), kidney (RPKM 13.2) and 19 other tissues.

Summary

This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]

DPCD Products(6)

mRNA	Protein	Name
NM_001329742.2	NP_001316671.1	protein DPCD isoform 1
NM_001329743.2	NP_001316672.1	protein DPCD isoform 3
NM_001329744.2	NP_001316673.1	protein DPCD isoform 4
NM_001329745.2	NP_001316674.1	protein DPCD isoform 5
NM_001329746.2	NP_001316675.1	protein DPCD isoform 6
NM_015448.3	NP_056263.1	protein DPCD isoform 2

DPCD Protein Structure

DPCD

0
100
203 a.a.

Protein Preferred Names

Protein Names

protein DPCD

RP11-529I10.4

Related Diseases

Diseases

Alias

Pulmonary Subvalvular Stenosis

Pulmonary Infundibular Stenosis	Congenital Infundibular Stenosis
Infundibular Pulmonic Stenosis	Infundibular Pulmonic Stenosis, Congenital
Subvalvular Pulmonic Stenosis

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Intellectual Developmental Disorder, Autosomal Dominant 29

MRD29	Autosomal Dominant Non-Syndromic Intellectual Disability 29
Mental Retardation, Autosomal Dominant 29	Autosomal Dominant Intellectual Developmental Disorder 29
Autosomal Dominant Mental Retardation 29	Mental Retardation, Autosomal Dominant, Type 29

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Intellectual Developmental Disorder, Autosomal Dominant 5

MRD5	Autosomal Dominant Non-Syndromic Intellectual Disability 5
Intellectual Disability, Autosomal Dominant 5	Mental Retardation, Autosomal Dominant 5
Autosomal Dominant Intellectual Developmental Disorder 5	Syngap1-Related Non-Syndromic Intellectual Disability
Autosomal Dominant Intellectual Disability 5	Syngap1 Syndrome
Syngap1-Related Nsid	Syngap1 Gene Mutation Linked To Intellectual Disability, Schizophrenia And Autism

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03946	DPCD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DPCD	MGD	MGI:1924407
Rattus norvegicus	DPCD	RGD	RGD:1307648
Macaca mulatta	DPCD	VGNC	VGNC:106036
Canis familiaris	DPCD	VGNC	VGNC:56112
Bos taurus	DPCD	VGNC	VGNC:55947

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