AOC1 - amine oxidase copper containing 1 Gene

Homo sapiens

Also known as ABP; DAO; KAO; ABP1; DAO1

Gene ID: 26 | Gene type: protein coding

About AOC1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,852,120-150,861,504 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and 2 paralogues. Biased expression in placenta (RPKM 229.3), kidney (RPKM 118.3) and 3 other tissues.

Summary

This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

AOC1 Products(2)

mRNA	Protein	Name
NM_001091.4	NP_001082.2	amiloride-sensitive amine oxidase [copper-containing] isoform 2 precursor
NM_001272072.2	NP_001259001.1	amiloride-sensitive amine oxidase [copper-containing] isoform 1 precursor

AOC1 Protein Structure

Cu_amine_oxidN2

Cu_amine_oxidN3

Cu_amine_oxid

0
200
400
600
751 a.a.

Protein Preferred Names

Protein Names

amiloride-sensitive amine oxidase [copper-containing]

amiloride binding protein 1 (amine oxidase (copper-containing))

Recombinant AOC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7497	ABP1/AOC1 Protein, Human (HEK293, His)	AAH14093.1 (E20-V751)	≥95%

Related Diseases

Diseases

Alias

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Trimethoprim Allergy

Primsol Allergy	Proloprim Allergy
Tmp Allergy

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Intestinal Disease

Intestinal Diseases

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal

Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia

Rhinitis

Runny Nose

Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Proctitis

Ulcerative Proctitis	Chronic Ulcerative Proctitis
Idiopathic Proctitis	Nonspecific Ulcerative Proctitis
Ulcerative Colitis Confined To Rectum	Ip - [Idiopathic Proctitis]
Chronic Ulcerative Proctitis Nos

Benign Ileal Neoplasm

Ileal Tumor	Ileal Neoplasms
Ileal Neoplasm

Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing

Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.	Acute Git Vascular Insuffic.
Acute Intestinal Ischemia	Acute Intestinal Vascular Insufficiency

Adermatoglyphia

ADERM	Immigration Delay Disease
Absence Of Fingerprints	Adg
Congenital Absence Of Fingerprints	Isolated Congenital Adermatoglyphia
Fingerprints, Absence Of	Skin Abnormalities

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-143721	SSAO inhibitor-2	Inhibitor	/	Unkown
HY-143723	SSAO inhibitor-3	Inhibitor	/	Unkown
HY-RS00771	AOC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AOC1	RGD	RGD:61296
Macaca mulatta	AOC1	VGNC	VGNC:70033
Canis familiaris	AOC1	VGNC	VGNC:37947
Bos taurus	AOC1	VGNC	VGNC:25972
Felis catus	AOC1	VGNC	VGNC:68565
Mus musculus	AOC1	MGD	MGI:1923757
Others	AOC1	NCBI

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