2. Gene
  3. AOC1 - amine oxidase copper containing 1 Gene

AOC1 - amine oxidase copper containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ABP; DAO; KAO; ABP1; DAO1

Gene ID: 26 | Gene type: protein coding

About AOC1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,852,120-150,861,504 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and 2 paralogues. Biased expression in placenta (RPKM 229.3), kidney (RPKM 118.3) and 3 other tissues.

Summary

This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

AOC1 Products(2)

mRNA Protein Name
NM_001091.4 NP_001082.2 amiloride-sensitive amine oxidase [copper-containing] isoform 2 precursor
NM_001272072.2 NP_001259001.1 amiloride-sensitive amine oxidase [copper-containing] isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
12072962 GOA
enables copper ion binding IDA
IDA: Inferred from direct assay
12072962 GOA
enables diamine oxidase activity IDA
IDA: Inferred from direct assay
8144586 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
19764817 GOA
enables histamine oxidase activity IDA
IDA: Inferred from direct assay
12072962 GOA
enables primary methylamine oxidase activity IDA
IDA: Inferred from direct assay
8144586 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19764817 GOA
enables putrescine oxidase activity IDA
IDA: Inferred from direct assay
7626074 GOA
Biological Process GO Annotation Evidence Reference Source
involved in putrescine metabolic process IMP
IMP: Inferred from mutant phenotype
8144586 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular exosome IDA
IDA: Inferred from direct assay
21082674 GOA
is active in extracellular space IDA
IDA: Inferred from direct assay
8144586 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
9399025 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
2217167 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AOC1 Protein Structure

Cu_amine_oxidN2

Cu_amine_oxidN2: Copper amine oxidase, N2 domain (39 - 125)

Cu_amine_oxidN3

Cu_amine_oxidN3: Copper amine oxidase, N3 domain (141 - 240)

Cu_amine_oxid

Cu_amine_oxid: Copper amine oxidase, enzyme domain (302 - 713)

  • 0
  • 200
  • 400
  • 600
  • 751 a.a.
Protein Preferred Names Protein Names

amiloride-sensitive amine oxidase [copper-containing]

amiloride binding protein 1 (amine oxidase (copper-containing))

AOC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AOC1 P19801 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
AOC1 P19801 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
AOC1 P19801 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra
AOC1 P19801 TIAL1 Homo sapiens Q01085-2
Validated Y2H
32296183
Intra
AOC1 P19801 RBPMS2 Homo sapiens Q6ZRY4
Validated Y2H
32296183
Intra
AOC1 P19801 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
AOC1 P19801 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
AOC1 P19801 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AOC1 Proteins

Cat. No. Product Name Accession Purity
HY-P7497 ABP1/AOC1 Protein, Human (HEK293, His) AAH14093.1 (E20-V751) ≥95%

Related Diseases

Diseases Alias
Food Allergy

Food Hypersensitivity

Food Allergies

Allergy Food

Food Allergen-Induced Hypersensitivity
Trimethoprim Allergy

Primsol Allergy

Proloprim Allergy

Tmp Allergy
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Intestinal Disease

Intestinal Diseases
Short Bowel Syndrome

Short Gut Syndrome

Acquired Short Bowel Syndrome

Secondary Short Bowel Syndrome

Short Bowel Nos
Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal
Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia
Rhinitis

Runny Nose
Autonomic Neuropathy

Diabetic Autonomic Neuropathy
Proctitis

Ulcerative Proctitis

Chronic Ulcerative Proctitis

Idiopathic Proctitis

Nonspecific Ulcerative Proctitis

Ulcerative Colitis Confined To Rectum

Ip - [Idiopathic Proctitis]

Chronic Ulcerative Proctitis Nos
Benign Ileal Neoplasm

Ileal Tumor

Ileal Neoplasms

Ileal Neoplasm
Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing
Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.

Acute Git Vascular Insuffic.

Acute Intestinal Ischemia

Acute Intestinal Vascular Insufficiency
Adermatoglyphia

ADERM

Immigration Delay Disease

Absence Of Fingerprints

Adg

Congenital Absence Of Fingerprints

Isolated Congenital Adermatoglyphia

Fingerprints, Absence Of

Skin Abnormalities
Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143721 SSAO inhibitor-2 Inhibitor / Unkown
HY-143723 SSAO inhibitor-3 Inhibitor / Unkown
HY-RS00771 AOC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AOC1 RGD RGD:61296
Macaca mulatta AOC1 VGNC VGNC:70033
Canis familiaris AOC1 VGNC VGNC:37947
Bos taurus AOC1 VGNC VGNC:25972
Felis catus AOC1 VGNC VGNC:68565
Mus musculus AOC1 MGD MGI:1923757
Others AOC1 NCBI