ZC3H10 - zinc finger CCCH-type containing 10 Gene

Homo sapiens

Also known as ZC3HDC10

Gene ID: 84872 | Gene type: protein coding

About ZC3H10

This gene has 5 transcripts (splice variants), 184 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.2), ovary (RPKM 4.7) and 25 other tissues.

Summary

Enables miRNA binding activity. Involved in negative regulation of production of miRNAs involved in gene silencing by miRNA and posttranscriptional regulation of gene expression. Predicted to be active in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZC3H10 Products(3)

mRNA	Protein	Name
NM_001303124.2	NP_001290053.1	zinc finger CCCH domain-containing protein 10
NM_001303125.2	NP_001290054.1	zinc finger CCCH domain-containing protein 10
NM_032786.3	NP_116175.1	zinc finger CCCH domain-containing protein 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables miRNA binding	IDA IDA: Inferred from direct assay	28431233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of miRNA processing	IDA IDA: Inferred from direct assay	28431233	GOA
acts upstream of positive effect post-transcriptional regulation of gene expression	IDA IDA: Inferred from direct assay	28431233	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	28431233	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3H10 Protein Structure

zf-CCCH

0
100
200
300
400
434 a.a.

Protein Preferred Names

Protein Names

zinc finger CCCH domain-containing protein 10

zinc finger CCCH-type domain containing 10

ZC3H10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZC3H10	Q96K80	PRR20C	Homo sapiens	P86479	Y2H Prey Pooling	25416956
Intra	ZC3H10	Q96K80	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	ZC3H10	Q96K80	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	ZC3H10	Q96K80	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	PICALM	Homo sapiens	Q13492-3	Y2H Array	32296183
Intra	ZC3H10	Q96K80	PICALM	Homo sapiens	Q13492-3	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	NFYA	Homo sapiens	P23511-2	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	NFYA	Homo sapiens	P23511-2	Y2H Array	32296183
Intra	ZC3H10	Q96K80	POU2F1	Homo sapiens	P14859-6	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	POU2F1	Homo sapiens	P14859-6	Y2H Array	32296183
Intra	ZC3H10	Q96K80	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	ZC3H10	Q96K80	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	ZC3H10	Q96K80	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	BOLL	Homo sapiens	Q8N9W6-4	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	BOLL	Homo sapiens	Q8N9W6-4	Y2H Array	32296183
Intra	ZC3H10	Q96K80	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Array	32296183
Intra	ZC3H10	Q96K80	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	ZC3H10	Q96K80	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	ZC3H10	Q96K80	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	ZC3H10	Q96K80	C10orf55	Homo sapiens	Q5SWW7	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	C10orf55	Homo sapiens	Q5SWW7	Y2H Array	32296183
Intra	ZC3H10	Q96K80	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	ZC3H10	Q96K80	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	ZC3H10	Q96K80	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	AOC1	Homo sapiens	P19801	Y2H Array	32296183
Intra	ZC3H10	Q96K80	AOC1	Homo sapiens	P19801	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	FOXH1	Homo sapiens	O75593	Y2H Array	32296183
Intra	ZC3H10	Q96K80	FOXH1	Homo sapiens	O75593	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	ZC3H10	Q96K80	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	FOSB	Homo sapiens	P53539	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	FOSB	Homo sapiens	P53539	Y2H Array	32296183
Intra	ZC3H10	Q96K80	RBM38	Homo sapiens	Q9H0Z9	Validated Y2H	32296183
Intra	ZC3H10	Q96K80	RBM38	Homo sapiens	Q9H0Z9	Y2H Array	32296183
Intra	ZC3H10	Q96K80	RBM38	Homo sapiens	Q9H0Z9	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	ZC3H10	Q96K80	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	ZC3H10	Q96K80	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	ZC3H10	Q96K80	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	ZC3H10	Q96K80	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	DAZAP2	Homo sapiens	Q15038	Y2H Array	19060904
Intra	ZC3H10	Q96K80	DAZAP2	Homo sapiens	Q15038	Y2H Pooling	19060904
Intra	ZC3H10	Q96K80	PLA2G10	Homo sapiens	O15496	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	PLA2G10	Homo sapiens	O15496	Y2H Array	32296183
Intra	ZC3H10	Q96K80	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	ZC3H10	Q96K80	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	ZC3H10	Q96K80	SPMIP9	Homo sapiens	Q96LM6	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	SPMIP9	Homo sapiens	Q96LM6	Validated Y2H	32296183
Intra	ZC3H10	Q96K80	SPMIP9	Homo sapiens	Q96LM6	Y2H Array	32296183
Intra	ZC3H10	Q96K80	NCS1	Homo sapiens	P62166	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	NCS1	Homo sapiens	P62166	Y2H Array	32296183
Intra	ZC3H10	Q96K80	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	ZC3H10	Q96K80	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	ZC3H10	Q96K80	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	TENT5B	Homo sapiens	Q96A09	Y2H Array	32296183
Intra	ZC3H10	Q96K80	TENT5B	Homo sapiens	Q96A09	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	DAB1	Homo sapiens	O75553	Y2H Prey Pooling	25416956
Intra	ZC3H10	Q96K80	DAB1	Homo sapiens	O75553	Y2H Array	25416956
Intra	ZC3H10	Q96K80	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	ZC3H10	Q96K80	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	ZC3H10	Q96K80	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	ZC3H10	Q96K80	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	ZC3H10	Q96K80	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	23275563
Intra	ZC3H10	Q96K80	KLHDC7B	Homo sapiens	Q96G42	Y2H Prey Pooling	32296183
Intra	ZC3H10	Q96K80	KLHDC7B	Homo sapiens	Q96G42	Y2H Array	32296183
Intra	ZC3H10	Q96K80	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	ZC3H10	Q96K80	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Optic Atrophy 11

OPA11

Atrophy, Optic, Type 11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15984	ZC3H10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZC3H10	VGNC	VGNC:37096
Mus musculus	ZC3H10	MGD	MGI:2143670
Canis familiaris	ZC3H10	VGNC	VGNC:48550
Macaca mulatta	ZC3H10	VGNC	VGNC:79554
Rattus norvegicus	ZC3H10	RGD	RGD:1587846

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