CHD5 - chromodomain helicase DNA binding protein 5 Gene

Homo sapiens

Also known as CHD-5; PMNDS

Gene ID: 26038 | Gene type: protein coding

About CHD5

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,101,787-6,180,321 (from NCBI)

This gene has 6 transcripts (splice variants), 171 orthologues, 30 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 14.5), testis (RPKM 9.9) and 1 other tissue.

Summary

This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]

CHD5 Products(1)

mRNA	Protein	Name
NM_015557.3	NP_056372.1	chromodomain-helicase-DNA-binding protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables H3K27me3 modified histone binding	IDA IDA: Inferred from direct assay	23948251	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	23948251	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23948251	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	21931736	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHD5 Protein Structure

CHDNT

PHD

Chromo

SNF2_N

Helicase_C

DUF1087

DUF1086

CHDCT2

0
400
800
1200
1600
1954 a.a.

Protein Preferred Names

Protein Names

chromodomain-helicase-DNA-binding protein 5

ATP-dependent helicase CHD5

Related Diseases

Diseases

Alias

Parenti-Mignot Neurodevelopmental Syndrome

PMNDS

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118780	CHD-5	Antagonist	≥98.0%	Unkown
HY-RS02610	CHD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHD5	VGNC	VGNC:59327
Macaca mulatta	CHD5	VGNC	VGNC:70959
Rattus norvegicus	CHD5	RGD	RGD:1582725
Mus musculus	CHD5	MGD	MGI:3036258
Felis catus	CHD5	VGNC	VGNC:60846
Canis familiaris	CHD5	VGNC	VGNC:39203

Name
Email *

	Sorry, but the email address you supplied was invalid.