DCAF4 - DDB1 and CUL4 associated factor 4 Gene

Homo sapiens

Also known as WDR21; WDR21A

Gene ID: 26094 | Gene type: protein coding

About DCAF4

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:72,926,464-72,962,098 (from NCBI)

This gene has 15 transcripts (splice variants), 89 orthologues and 26 paralogues. Ubiquitous expression in thyroid (RPKM 4.7), testis (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 Ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

DCAF4 Products(8)

mRNA	Protein	Name
NM_001163508.2	NP_001156980.1	DDB1- and CUL4-associated factor 4 isoform 4
NM_001163509.2	NP_001156981.1	DDB1- and CUL4-associated factor 4 isoform 5
NM_001352447.2	NP_001339376.1	DDB1- and CUL4-associated factor 4 isoform 6
NM_001352448.3	NP_001339377.1	DDB1- and CUL4-associated factor 4 isoform 7
NM_001352449.2	NP_001339378.1	DDB1- and CUL4-associated factor 4 isoform 8
NM_015604.4	NP_056419.2	DDB1- and CUL4-associated factor 4 isoform 1
NM_181340.3	NP_851937.1	DDB1- and CUL4-associated factor 4 isoform 2
NM_181341.3	NP_851938.2	DDB1- and CUL4-associated factor 4 isoform 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19966799	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF4 Protein Structure

WD40

0
100
200
300
400
495 a.a.

Protein Preferred Names

Protein Names

DDB1- and CUL4-associated factor 4

WD repeat domain 21A

Related Diseases

Diseases

Alias

Microphthalmia, Isolated 2

Isolated Microphthalmia 2	MCOP2
Anophthalmia, Clinical, Isolated	Microphthalmia, Isolated, 2
Isolated Clinical Anophthalmia	Microphthalmia, Isolated, Type 2

Atrial Septal Defect 9

ASD9	Atrial Heart Septal Defect 9
Septal Defect, Atrial, Type 9

Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E	Xeroderma Pigmentosum V
Xp Group E	Xp5
Xpe	Xeroderma Pigmentosum, Complementation Group E

Isolated Microphthalmia

Retroperitoneal Leiomyosarcoma

Atrial Septal Defect 5

ASD5	Atrial Heart Septal Defect 5
Septal Defect, Atrial, Type 5

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03564	DCAF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03565	DCAF4L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DCAF4	RGD	RGD:1306241
Canis familiaris	DCAF4	VGNC	VGNC:50445
Mus musculus	DCAF4	MGD	MGI:1921078
Macaca mulatta	DCAF4	VGNC	VGNC:84331
Others	DCAF4	NCBI

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