TRPC4AP - transient receptor potential cation channel subfamily C member 4 associated protein Gene

Homo sapiens

Also known as TRUSS; TRRP4AP; PPP1R158; C20orf188

Gene ID: 26133 | Gene type: protein coding

About TRPC4AP

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,002,404-35,092,807 (from NCBI)

This gene has 2 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in placenta (RPKM 20.6), spleen (RPKM 19.3) and 25 other tissues.

Summary

Enables Phosphatase binding activity and ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin Ligase complex. Is active in Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

TRPC4AP Products(2)

mRNA	Protein	Name
NM_015638.3	NP_056453.1	short transient receptor potential channel 4-associated protein isoform a
NM_199368.2	NP_955400.1	short transient receptor potential channel 4-associated protein isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IDA IDA: Inferred from direct assay	19389623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19389623	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	29779948	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	20551172	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20551172	GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: Inferred from direct assay	29779948	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29779948	GOA
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	20551172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC4AP Protein Structure

DUF3689

0
200
400
600
797 a.a.

Protein Preferred Names

Protein Names

short transient receptor potential channel 4-associated protein

TNF-receptor ubiquitous scaffolding/signaling protein

TRPC4AP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRPC4AP	Q8TEL6	PPP1CA	Homo sapiens	P62136	Far-WB	19389623

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15107	TRPC4AP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRPC4AP	VGNC	VGNC:66584
Mus musculus	TRPC4AP	MGD	MGI:1930751
Canis familiaris	TRPC4AP	VGNC	VGNC:47869
Bos taurus	TRPC4AP	VGNC	VGNC:36384
Macaca mulatta	TRPC4AP	VGNC	VGNC:79014
Rattus norvegicus	TRPC4AP	RGD	RGD:1309914

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