2. Gene
  3. PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP1A; PP-1A; PPP1A; PP1alpha

Gene ID: 5499 | Gene type: protein coding

About PPP1CA

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,398,183-67,401,858 (from NCBI)

This gene has 14 transcripts (splice variants), 177 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 67.2), colon (RPKM 56.9) and 25 other tissues.

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of Cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

PPP1CA Products(3)

mRNA Protein Name
NM_001008709.2 NP_001008709.1 serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3
NM_002708.4 NP_002699.1 serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1
NM_206873.2 NP_996756.1 serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cadherin binding involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
25468996 GOA
enables iron ion binding IDA
IDA: Inferred from direct assay
30403291 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10807923 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
28216226 GOA
enables transition metal ion binding IDA
IDA: Inferred from direct assay
30403291 GOA
Biological Process GO Annotation Evidence Reference Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
22311981 GOA
acts upstream of or within protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
22801782 GOA
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
22311981 GOA
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
21712997 GOA
involved in telomere maintenance in response to DNA damage IDA
IDA: Inferred from direct assay
28216226 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PTW/PP1 phosphatase complex IDA
IDA: Inferred from direct assay
20516061 GOA
located in adherens junction IDA
IDA: Inferred from direct assay
25468996 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11739654 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11739654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1CA Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (59 - 250)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

protein phosphatase 1, catalytic subunit, alpha isozyme

PPP1CA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP1CA P62136 KNL1 Homo sapiens Q8NG31
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R7 Homo sapiens Q15435
TAP
27173435
Intra
PPP1CA P62136 PPP1R7 Homo sapiens Q15435
Anti Bait CoIP
25593058
Intra
PPP1CA P62136 PPP1R7 Homo sapiens Q15435
BioID
28330616
Intra
PPP1CA P62136 PPP1R7 Homo sapiens Q15435
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R2B Homo sapiens Q6NXS1
Y2H Prey Pooling
25416956
Intra
PPP1CA P62136 PPP1R16B Homo sapiens Q96T49
Y2H Array
32296183
Intra
PPP1CA P62136 PPP1R16B Homo sapiens Q96T49
Validated Y2H
32296183
Intra
PPP1CA P62136 PPP1R16B Homo sapiens Q96T49
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 PPP1R3D Homo sapiens O95685
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R3D Homo sapiens O95685
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R3D Homo sapiens O95685
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 EIF2S1 Homo sapiens P05198
Phosphatase Assay
26095357
Intra
PPP1CA P62136 EIF2S1 Homo sapiens P05198
BiFC
26095357
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
Filter Binding
10807923
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
NMR
20826336
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
GMS
20826336
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
SAXS
20826336
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
BioID
28330616
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
Pull Down
20826336
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
Anti Bait CoIP
25593058
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R2 Homo sapiens P41236
TAP
27173435
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
Y2H
15231748
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
BioID
28330616
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra
PPP1CA P62136 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1-2
Validated Y2H
32296183
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1-2
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1-2
Y2H Array
32296183
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1-2
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 PPP1R10 Homo sapiens Q96QC0
BioID
28330616
Intra
PPP1CA P62136 PPP1R10 Homo sapiens Q96QC0
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R10 Homo sapiens Q96QC0
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R10 Homo sapiens Q96QC0
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-2
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-2
Validated Y2H
32296183
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-2
Y2H Array
32296183
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-2
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-1
ITC
22940584
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-1
Ion Exchange Chrom
22940584
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-1
X-Ray Diffraction
22940584
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-1
Pull Down
22940584
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-1
GMS
22940584
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972-1
NMR
22940584
Intra
PPP1CA P62136 AATK Homo sapiens Q6ZMQ8
Ub Reconstruction
28065597
Intra
PPP1CA P62136 CEP192 Homo sapiens Q8TEP8
Pull Down
19389623
Intra
PPP1CA P62136 CEP192 Homo sapiens Q8TEP8
Far-WB
19389623
Intra
PPP1CA P62136 PPP1R3C Homo sapiens Q9UQK1
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 PPP1R3C Homo sapiens Q9UQK1
Validated Y2H
32296183
Intra
PPP1CA P62136 PPP1R3C Homo sapiens Q9UQK1
Y2H
22321011
Intra
PPP1CA P62136 PPP1R3C Homo sapiens Q9UQK1
Y2H Array
32296183
Intra
PPP1CA P62136 PPP1R18 Homo sapiens Q6NYC8
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R18 Homo sapiens Q6NYC8
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R18 Homo sapiens Q6NYC8
BioID
28330616
Intra
PPP1CA P62136 PPP1R18 Homo sapiens Q6NYC8
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R18 Homo sapiens Q6NYC8
Anti Bait CoIP
25593058
Intra
PPP1CA P62136 TRPC4AP Homo sapiens Q8TEL6
Pull Down
19389623
Intra
PPP1CA P62136 TOR1AIP1 Homo sapiens Q5JTV8
Anti Bait CoIP
24116158
Intra
PPP1CA P62136 TOR1AIP1 Homo sapiens Q5JTV8
Y2H
22321011
Intra
PPP1CA P62136 SYTL2 Homo sapiens Q9HCH5
Y2H
15231748
Intra
PPP1CA P62136 PPP1R15B Homo sapiens Q5SWA1
Y2H
15231748
Intra
PPP1CA P62136 PPP1R15B Homo sapiens Q5SWA1
Y2H
21382349
Intra
PPP1CA P62136 PPP1R15B Homo sapiens Q5SWA1
BioID
28330616
Intra
PPP1CA P62136 PPP1R15B Homo sapiens Q5SWA1
Pull Down
28330616
Intra
PPP1CA P62136 ZFYVE9 Homo sapiens O95405
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 ZFYVE9 Homo sapiens O95405
Y2H
15231748
Intra
PPP1CA P62136 ZFYVE16 Homo sapiens Q7Z3T8
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 ZFYVE16 Homo sapiens Q7Z3T8
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 SKP1 Homo sapiens P63208
Anti Bait CoIP
17274640
Intra
PPP1CA P62136 SKP1 Homo sapiens P63208
Anti Bait CoIP
38057879
Intra
PPP1CA P62136 PPP1R26 Homo sapiens Q5T8A7
Pull Down
19389623
Intra
PPP1CA P62136 PLCL2 Homo sapiens Q9UPR0
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PLCL2 Homo sapiens Q9UPR0
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 BRCA1 Homo sapiens P38398
Anti Tag CoIP
17511879
Intra
PPP1CA P62136 BRCA1 Homo sapiens P38398
Anti Bait CoIP
17511879
Intra
PPP1CA P62136 PPP1R9B Homo sapiens Q96SB3
Y2H
22321011
Intra
PPP1CA P62136 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R9B Homo sapiens Q96SB3
Anti Bait CoIP
25593058
Intra
PPP1CA P62136 PPP1R9B Homo sapiens Q96SB3
Anti Bait CoIP
25785436
Intra
PPP1CA P62136 PPP1R9B Homo sapiens Q96SB3
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R9B Homo sapiens Q96SB3
Y2H
15231748
Intra
PPP1CA P62136 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 VCP Homo sapiens P55072
Anti Bait CoIP
25593058
Intra
PPP1CA P62136 KIF18A Homo sapiens Q8NI77
Y2H
15231748
Intra
PPP1CA P62136 KIF18A Homo sapiens Q8NI77
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 KIF18A Homo sapiens Q8NI77
TAP
27173435
Intra
PPP1CA P62136 KIF18A Homo sapiens Q8NI77
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 YBX3 Homo sapiens P16989
IF
25593058
Intra
PPP1CA P62136 YBX3 Homo sapiens P16989
Anti Bait CoIP
25593058
Intra
PPP1CA P62136 RRP1B Homo sapiens Q14684
Far-WB
20926688
Intra
PPP1CA P62136 RRP1B Homo sapiens Q14684
Pull Down
19389623
Intra
PPP1CA P62136 CDC5L Homo sapiens Q99459
Phosphatase Assay
22940584
Intra
PPP1CA P62136 PPP1R3B Homo sapiens Q86XI6
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 PPP1R3B Homo sapiens Q86XI6
Validated Y2H
32296183
Intra
PPP1CA P62136 PPP1R3B Homo sapiens Q86XI6
Y2H Array
32296183
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1
Y2H
22321011
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1
Pull Down
28330616
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1
BioID
28330616
Intra
PPP1CA P62136 TPRN Homo sapiens Q4KMQ1
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 TSC2 Homo sapiens P49815
Far-WB
19389623
Intra
PPP1CA P62136 TSC2 Homo sapiens P49815
Pull Down
19389623
Intra
PPP1CA P62136 CSRNP1 Homo sapiens Q96S65
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 CSRNP1 Homo sapiens Q96S65
Validated Y2H
32296183
Intra
PPP1CA P62136 CSRNP1 Homo sapiens Q96S65
Y2H
22321011
Intra
PPP1CA P62136 CSRNP1 Homo sapiens Q96S65
Y2H Array
32296183
Intra
PPP1CA P62136 CSRNP1 Homo sapiens Q96S65
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 CSRNP1 Homo sapiens Q96S65
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 CSRNP1 Homo sapiens Q96S65
Y2H Prey Pooling
25416956
Intra
PPP1CA P62136 SAXO4 Homo sapiens Q7Z5V6
Far-WB
19389623
Intra
PPP1CA P62136 ZFYVE1 Homo sapiens Q9HBF4
Pull Down
19389623
Intra
PPP1CA P62136 APAF1 Homo sapiens O14727
Antibody Array
17274640
Intra
PPP1CA P62136 APAF1 Homo sapiens O14727
Anti Bait CoIP
17274640
Intra
PPP1CA P62136 WNK1 Homo sapiens Q9H4A3
Pull Down
19389623
Intra
PPP1CA P62136 RB1 Homo sapiens P06400
Antibody Array
17274640
Intra
PPP1CA P62136 RB1 Homo sapiens P06400
Pull Down
8384581
Intra
PPP1CA P62136 SPRED1 Homo sapiens Q7Z699
Far-WB
19389623
Intra
PPP1CA P62136 TMEM132D Homo sapiens Q14C87
Pull Down
19389623
Intra
PPP1CA P62136 PPP1R27 Homo sapiens Q86WC6
Y2H Array
32296183
Intra
PPP1CA P62136 PPP1R27 Homo sapiens Q86WC6
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 PPP1R27 Homo sapiens Q86WC6
Far-WB
19389623
Intra
PPP1CA P62136 PPP1R27 Homo sapiens Q86WC6
Validated Y2H
32296183
Intra
PPP1CA P62136 PPP1R27 Homo sapiens Q86WC6
Pull Down
19389623
Intra
PPP1CA P62136 PPP1R37 Homo sapiens O75864
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R37 Homo sapiens O75864
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R37 Homo sapiens O75864
BioID
28330616
Intra
PPP1CA P62136 PPP1R37 Homo sapiens O75864
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R37 Homo sapiens O75864
Pull Down
19389623
Intra
PPP1CA P62136 MPHOSPH10 Homo sapiens O00566
Y2H
15231748
Intra
PPP1CA P62136 MPHOSPH10 Homo sapiens O00566
Pull Down
19389623
Intra
PPP1CA P62136 CSRNP2 Homo sapiens Q9H175
Pull Down
19389623
Intra
PPP1CA P62136 CSRNP2 Homo sapiens Q9H175
Y2H Prey Pooling
32296183
Intra
PPP1CA P62136 CSRNP2 Homo sapiens Q9H175
Validated Y2H
32296183
Intra
PPP1CA P62136 CSRNP2 Homo sapiens Q9H175
Y2H Array
25416956
Intra
PPP1CA P62136 CSRNP2 Homo sapiens Q9H175
Y2H Array
32296183
Intra
PPP1CA P62136 CSRNP2 Homo sapiens Q9H175
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 CSRNP2 Homo sapiens Q9H175
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 LRRK2 Homo sapiens Q5S007
PPase Assay
23937259
Intra
PPP1CA P62136 LRRK2 Homo sapiens Q5S007
PLA
23937259
Intra
PPP1CA P62136 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
23937259
Intra
PPP1CA P62136 PPP1R13L Homo sapiens Q8WUF5
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R13L Homo sapiens Q8WUF5
TAP
27173435
Intra
PPP1CA P62136 PPP1R13L Homo sapiens Q8WUF5
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R13L Homo sapiens Q8WUF5
Y2H
22321011
Intra
PPP1CA P62136 PPP1R13L Homo sapiens Q8WUF5
Anti Tag CoIP
21998301
Intra
PPP1CA P62136 PPP1R13L Homo sapiens Q8WUF5
BioID
28330616
Intra
PPP1CA P62136 PPP1R13L Homo sapiens Q8WUF5
Pull Down
28330616
Intra
PPP1CA P62136 PTEN Homo sapiens P60484
Antibody Array
17274640
Intra
PPP1CA P62136 AXIN1 Homo sapiens O15169
Anti Bait CoIP
17318175
Intra
PPP1CA P62136 AXIN1 Homo sapiens O15169
Anti Tag CoIP
17318175
Intra
PPP1CA P62136 RIF1 Homo sapiens Q5UIP0
BioID
28330616
Intra
PPP1CA P62136 RIF1 Homo sapiens Q5UIP0
Pull Down
28330616
Intra
PPP1CA P62136 RIF1 Homo sapiens Q5UIP0
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 RIF1 Homo sapiens Q5UIP0
TAP
27173435
Intra
PPP1CA P62136 YLPM1 Homo sapiens P49750
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 YLPM1 Homo sapiens P49750
Y2H
22321011
Intra
PPP1CA P62136 YLPM1 Homo sapiens P49750
BioID
28330616
Intra
PPP1CA P62136 YLPM1 Homo sapiens P49750
Pull Down
28330616
Intra
PPP1CA P62136 WBP11 Homo sapiens Q9Y2W2
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 WBP11 Homo sapiens Q9Y2W2
TAP
27173435
Intra
PPP1CA P62136 WBP11 Homo sapiens Q9Y2W2
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 PPP1R15A Homo sapiens O75807
BiFC
26095357
Intra
PPP1CA P62136 PPP1R15A Homo sapiens O75807
Pull Down
26095357
Intra
PPP1CA P62136 PPP1R15A Homo sapiens O75807
ITC
26095357
Intra
PPP1CA P62136 PPP1R15A Homo sapiens O75807
X-Ray Diffraction
26095357
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972
BioID
28330616
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972
Pull Down
28330616
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972
TAP
27173435
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972
Y2H
15231748
Intra
PPP1CA P62136 PPP1R8 Homo sapiens Q12972
Anti Bait CoIP
25593058
Intra
PPP1CA P62136 SH2D4A Homo sapiens Q9H788
Pull Down
19389623
Intra
PPP1CA P62136 CNST Homo sapiens Q6PJW8
Anti Tag CoIP
28514442
Intra
PPP1CA P62136 CNST Homo sapiens Q6PJW8
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 CNST Homo sapiens Q6PJW8
Pull Down
19389623
Intra
PPP1CA P62136 TP53BP2 Homo sapiens Q13625
BioID
28330616
Intra
PPP1CA P62136 TP53BP2 Homo sapiens Q13625
Anti Tag CoIP
33961781
Intra
PPP1CA P62136 TP53BP2 Homo sapiens Q13625
Anti Tag CoIP
21998301
Intra
PPP1CA P62136 TP53BP2 Homo sapiens Q13625
Pull Down
28330616
Cross
PPP1CA P62136 Clock Mus musculus O08785
Y2H
23555304
Intra
PPP1CA P62136 DLG3 Homo sapiens Q92796
Far-WB
19389623
Intra
PPP1CA P62136 FOXP3 Homo sapiens Q9BZS1
Anti Bait CoIP
23396208
Intra
PPP1CA P62136 SGO2 Homo sapiens Q562F6
Anti Tag CoIP
21666598
Cross
PPP1CA P62136 N Middle East respiratory syndrome-related coronavirus K9N4V7
P8 Filamentous Phage
34799561
Cross
PPP1CA P62136 N Middle East respiratory syndrome-related coronavirus K9N4V7
Phage Display
37100772
Cross
PPP1CA P62136 ICP34.5 Human herpesvirus 1 P36313
BiFC
18068675
Cross
PPP1CA P62136 Ppp1r9a Rattus norvegicus O35867
X-Ray Diffraction
20305656
Cross
PPP1CA P62136 Ppp1r9a Rattus norvegicus O35867
GMS
20305656
Cross
PPP1CA P62136 Ppp1r9a Rattus norvegicus O35867
Pull Down
20305656
Cross
PPP1CA P62136 Ppp1r9b Rattus norvegicus O35274
X-Ray Diffraction
20305656
Cross
PPP1CA P62136 Ppp1r9b Rattus norvegicus O35274
Anti Tag CoIP
25785436
Cross
PPP1CA P62136 Ppp1r9b Rattus norvegicus O35274
GMS
20305656
Cross
PPP1CA P62136 Ppp1r9b Rattus norvegicus O35274
Pull Down
20305656
Cross
PPP1CA P62136 Ppp1r9b Rattus norvegicus O35274
SAXS
21094159
Cross
PPP1CA P62136 Ppp1r9b Rattus norvegicus O35274
ITC
20305656
Cross: Cross-species interaction Intra: Intraspecies interaction

PPP1CA Antibodies

Cat. No. Product Name Application Reactivity
HY-P81305 PP1C alpha Antibody (YA1040) WB, IHC-F, IHC-P, ICC/IF Human
HY-P81305A PP1C alpha Antibody (YA1041) WB, ICC/IF Human
HY-P81955 PP1C alpha/beta Antibody (YA1700) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]
Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
Coronavirus Infectious Disease
Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation
Viral Pneumonia

Pneumonia, Viral

Acute Viral Pneumonia

Bronchopneumonia Due To Viruses Other Than Influenza Viruses

Interstitial Viral Pneumonia

Viral Bronchopneumonia

Viral Double Pneumonia

Viral Lobar Pneumonia

Viral Purulent Pneumonia

Virus Interstitial Pneumonia

Virus Lobar Pneumonia
Acute Diarrhea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10973 PPP1CA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPP1CA VGNC VGNC:106874
Felis catus PPP1CA VGNC VGNC:105823
Rattus norvegicus PPP1CA RGD RGD:3375
Mus musculus PPP1CA MGD MGI:103016
Macaca mulatta PPP1CA VGNC VGNC:76366