PPP1CA - protein phosphatase 1 catalytic subunit alpha Gene

Homo sapiens

Also known as PP1A; PP-1A; PPP1A; PP1alpha

Gene ID: 5499 | Gene type: protein coding

About PPP1CA

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,398,183-67,401,858 (from NCBI)

This gene has 14 transcripts (splice variants), 177 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 67.2), colon (RPKM 56.9) and 25 other tissues.

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein Phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein Phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of Cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

PPP1CA Products(3)

mRNA	Protein	Name
NM_001008709.2	NP_001008709.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3
NM_002708.4	NP_002699.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1
NM_206873.2	NP_996756.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2

PPP1CA Protein Structure

Metallophos

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

protein phosphatase 1, catalytic subunit, alpha isozyme

Related Diseases

Diseases

Alias

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Ebola Hemorrhagic Fever

Ebola Virus Disease	Viral Hemorrhagic Fever
Hemorrhagic Fever, Ebola	Ebola
Ehf	Ebola Fever
Hemorrhagic Fevers, Viral	Ebola Haemorrhagic Fever
Ebod - [Ebola Disease]	Evd - [Ebola Virus Disease]
Ebola Virus Haemorrhagic Fever	Vhf - [Viral Haemorrhagic Fever] Nos
Viral Haemorrhagic Fever, Not Otherwise Specified

Croup

Acute Obstructive Laryngitis	Laryngotracheobronchitis
Acute Laryngotracheobronchitis	Croup Syndrome
Acute Laryngitis With Obstruction	Obstructive Laryngitis
Obstructive Laryngitis Nos	Obstructive Laryngotracheitis Nos

Coronavirus Infectious Disease

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Viral Pneumonia

Pneumonia, Viral	Acute Viral Pneumonia
Bronchopneumonia Due To Viruses Other Than Influenza Viruses	Interstitial Viral Pneumonia
Viral Bronchopneumonia	Viral Double Pneumonia
Viral Lobar Pneumonia	Viral Purulent Pneumonia
Virus Interstitial Pneumonia	Virus Lobar Pneumonia

Acute Diarrhea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10973	PPP1CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP1CA	VGNC	VGNC:106874
Felis catus	PPP1CA	VGNC	VGNC:105823
Rattus norvegicus	PPP1CA	RGD	RGD:3375
Mus musculus	PPP1CA	MGD	MGI:103016
Macaca mulatta	PPP1CA	VGNC	VGNC:76366

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