2. Gene
  3. Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cot; Est; Estf; Tpl2; Tpl-2; c-COT; Cot/Tpl2

Gene ID: 26410 | Gene type: protein coding

About Map3k8

Chromosome 18: 4,331,327-4,353,015 reverse strand.GRCm39:CM001011.3

This gene has 5 transcripts (splice variants), 199 orthologues, 35 paralogues and is associated with 34 phenotypes. Ubiquitous expression in spleen adult (RPKM 3.1), lung adult (RPKM 2.9) and 27 other tissues.

Summary

Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in protein phosphorylation and signal transduction. Predicted to act upstream of or within immune system process and phosphorylation. Predicted to be located in cytosol. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; hemolymphoid system gland; and reproductive system. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Map3k8 Products(1)

mRNA Protein Name
NM_007746.2 NP_031772.1 mitogen-activated protein kinase kinase kinase 8

Map3k8 Protein Structure

STKc_MAP3K8

STKc_MAP3K8: cd13995 (132 - 387)

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  • 467 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 8

COT proto-oncogene serine/threonine-protein kinase

cancer Osaka thyroid oncogene

proto-oncogene c-Cot

serine/threonine-protein kinase cot

tumor progression locus 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12358 Tpl2 Kinase Inhibitor 1 Inhibitor 99.22% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k8 NCBI NCBI:1326