2. Gene
  3. Mapk1 - mitogen-activated protein kinase 1 Gene

Mapk1 - mitogen-activated protein kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ERK; Erk2; MAPK2; PRKM2; Prkm1; p41mapk; p42mapk; 9030612K14Rik

Gene ID: 26413 | Gene type: protein coding

About Mapk1

Chromosome 16: 16,801,246-16,865,317 forward strand.GRCm39:CM001009.3

This gene has 9 transcripts (splice variants), 214 orthologues, 19 paralogues and is associated with 35 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues.

Summary

Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein kinase activity. Involved in peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and response to nicotine. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and cellular response to cytokine stimulus. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapk1 Products(3)

mRNA Protein Name
NM_011949.3 NP_036079.1 mitogen-activated protein kinase 1
NM_001357115.1 NP_001344044.1 mitogen-activated protein kinase 1
NM_001038663.1 NP_001033752.1 mitogen-activated protein kinase 1

Mapk1 Protein Structure

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (16 - 350)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 1

ERK-2

ERT1

MAP kinase 1

MAP kinase 2

MAPK 1

MAPK 2

extracellular signal-regulated kinase 2

mitogen-activated protein kinase 2

p42-MAPK

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10406 Talmapimod Inhibitor 98.97% Phase 2
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13285 Ki16425 Antagonist 98.11% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-P2456 MBP MAPK Substrate 99.71% Unkown
HY-N2232 N-​Feruloyloctopamine Inhibitor 99.91% Unkown
HY-10406A Talmapimod hydrochloride Inhibitor / Unkown
HY-149921 Antiangiogenic agent 3 / Unkown
HY-152087 DCZ19931 Inhibitor / Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-N3487 Isodorsmanin A / Unkown
HY-P0141 Akt/SKG Substrate Peptide / Unkown
HY-P0141A Akt/SKG Substrate Peptide TFA / Unkown
HY-RS08092 MAPK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08093 Mapk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08094 Mapk1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk1 NCBI NCBI:5594