Mapk1 - mitogen-activated protein kinase 1 Gene

Mus musculus

Also known as ERK; Erk2; MAPK2; PRKM2; Prkm1; p41mapk; p42mapk; 9030612K14Rik

Gene ID: 26413 | Gene type: protein coding

About Mapk1

Chromosome 16: 16,801,246-16,865,317 forward strand.GRCm39:CM001009.3

This gene has 9 transcripts (splice variants), 214 orthologues, 19 paralogues and is associated with 35 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues.

Summary

Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein kinase activity. Involved in peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and response to nicotine. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and cellular response to cytokine stimulus. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapk1 Products(3)

mRNA	Protein	Name
NM_011949.3	NP_036079.1	mitogen-activated protein kinase 1
NM_001357115.1	NP_001344044.1	mitogen-activated protein kinase 1
NM_001038663.1	NP_001033752.1	mitogen-activated protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	1659995	MGI
enables MAP kinase activity	IMP IMP: Inferred from mutant phenotype	11841548	MGI
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	12721286	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	26267534	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	12808090	MGI
enables phosphatase binding	IPI IPI: Inferred from physical interaction	8221888	MGI
enables phosphotyrosine residue binding	IMP IMP: Inferred from mutant phenotype	14636584	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10419510	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	14744933	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11854404	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9254656	MGI
acts upstream of or within Bergmann glial cell differentiation	IGI IGI: Inferred from genetic interaction	24431450	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	15383658	MGI
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	24493648	MGI
acts upstream of or within ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	19047410	MGI
acts upstream of or within MAPK cascade	IDA IDA: Inferred from direct assay	8626447	MGI
involved in MAPK cascade	IGI IGI: Inferred from genetic interaction	21220101	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9064344	MGI
acts upstream of or within animal organ morphogenesis	IDA IDA: Inferred from direct assay	11684667	MGI
acts upstream of or within cardiac neural crest cell development involved in heart development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within cellular response to tumor necrosis factor	IGI IGI: Inferred from genetic interaction	24349514	MGI
acts upstream of or within cytosine metabolic process	IDA IDA: Inferred from direct assay	15284227	MGI
acts upstream of or within face development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within face development	IMP IMP: Inferred from mutant phenotype	18952847	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	18952847	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	20056832	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	14997210	MGI
acts upstream of or within labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	14622137	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	20661302	MGI
acts upstream of or within lung morphogenesis	IGI IGI: Inferred from genetic interaction	25100655	MGI
acts upstream of or within mammary gland epithelial cell proliferation	IDA IDA: Inferred from direct assay	18604197	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within negative regulation of cell differentiation	IGI IGI: Inferred from genetic interaction	14970190	MGI
acts upstream of or within neural crest cell development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within outer ear morphogenesis	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	18084034	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	11854404	MGI
acts upstream of or within peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18084034	MGI
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	11854404	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11841548	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15896720	MGI
acts upstream of or within regulation of cellular pH	IMP IMP: Inferred from mutant phenotype	26375174	MGI
acts upstream of or within regulation of ossification	IGI IGI: Inferred from genetic interaction	20053668	MGI
acts upstream of or within response to exogenous dsRNA	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12872135	MGI
involved in response to nicotine	IGI IGI: Inferred from genetic interaction	11404397	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within trachea formation	IGI IGI: Inferred from genetic interaction	25100655	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11726647	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	22451653	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9447983	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11884367	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11726647	MGI
located in pseudopodium	IDA IDA: Inferred from direct assay	12821670	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk1 Protein Structure

STKc_ERK1_2_like

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 1

ERK-2	ERT1
MAP kinase 1	MAP kinase 2
MAPK 1	MAPK 2
extracellular signal-regulated kinase 2	mitogen-activated protein kinase 2
p42-MAPK

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10406	Talmapimod	Inhibitor	98.97%	Phase 2
HY-10406A	Talmapimod hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13285	Ki16425	Antagonist	98.11%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-P2456	MBP MAPK Substrate		99.71%	Unkown
HY-N2232	N-Feruloyloctopamine	Inhibitor	99.91%	Unkown
HY-149921	Antiangiogenic agent 3		/	Unkown
HY-152087	DCZ19931	Inhibitor	/	Unkown
HY-N12726	Halociline	Inhibitor	/	Unkown
HY-N3487	Isodorsmanin A		/	Unkown
HY-P0141	Akt/SKG Substrate Peptide		/	Unkown
HY-P0141A	Akt/SKG Substrate Peptide TFA		/	Unkown
HY-RS08092	MAPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08093	Mapk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08094	Mapk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk1	NCBI	NCBI:5594

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