TIMM9 - translocase of inner mitochondrial membrane 9 Gene

Homo sapiens

Also known as TIM9; TIM9A

Gene ID: 26520 | Gene type: protein coding

About TIMM9

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,408,494-58,427,531 (from NCBI)

This gene has 10 transcripts (splice variants) and 167 orthologues. Ubiquitous expression in thyroid (RPKM 11.9), ovary (RPKM 11.7) and 25 other tissues.

Summary

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

TIMM9 Products(8)

mRNA	Protein	Name
NM_001304485.2	NP_001291414.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304486.1	NP_001291415.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304487.2	NP_001291416.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304488.1	NP_001291417.1	mitochondrial import inner membrane translocase subunit Tim9 isoform b
NM_001304489.1	NP_001291418.1	mitochondrial import inner membrane translocase subunit Tim9 isoform c
NM_001304490.1	NP_001291419.1	mitochondrial import inner membrane translocase subunit Tim9 isoform d
NM_001304491.1	NP_001291420.1	mitochondrial import inner membrane translocase subunit Tim9 isoform d
NM_012460.4	NP_036592.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables membrane insertase activity	IDA IDA: Inferred from direct assay	16387659	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14726512	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16387659	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	16387659	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein insertion into mitochondrial inner membrane	IDA IDA: Inferred from direct assay	16387659	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TIM22 mitochondrial import inner membrane insertion complex	IPI IPI: Inferred from physical interaction	32901109	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	14726512	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IDA IDA: Inferred from direct assay	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IPI IPI: Inferred from physical interaction	14726512	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIMM9 Protein Structure

zf-Tim10_DDP

0
89 a.a.

Protein Preferred Names

Protein Names

mitochondrial import inner membrane translocase subunit Tim9

translocase of inner mitochondrial membrane 9 homolog

TIMM9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TIMM9	Q9Y5J7	TIMM10	Homo sapiens	P62072	Anti Bait CoIP	14726512
Intra	TIMM9	Q9Y5J7	TIMM10	Homo sapiens	P62072	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mohr-Tranebjaerg Syndrome

Deafness-Dystonia-Optic Neuronopathy Syndrome	Jensen Syndrome
Deafness Dystonia Syndrome	MTS
Dds	Deafness-Dystonia-Optic Atrophy Syndrome
Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency	Opticoacoustic Nerve Atrophy With Dementia
Dystonia-Deafness Syndrome	Ddp
Ddon Syndrome	Mohr-Tranebjærg Syndrome
Deafness Dystonia Optic Atrophy Syndrome	Deafness Dystonia Optic Neuronopathy Syndrome
Dystonia Deafness Syndrome	Ddon
Deafness - Dystonia - Optic Neuronopathy Syndrome	Deafness-Dystonia-Optic Neuronopathy Syndrome
Hearing Loss-Dystonia-Optic Neuronopathy Syndrome	Dfn-1
X-Linked Progressive Deafness Type 1

Myoclonic Epilepsy, Juvenile 3

Myoclonic Epilepsy, Juvenile, Susceptibility To, 3	EJM3
Epilepsy, Juvenile Myoclonic 3	Juvenile Myoclonic Epilepsy 3

Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Visual Cortex Disease

Visual Cortex Dysfunction	Visual Cortex Disorder
Visual Cortical Disorder	Disease Of Visual Cortex

Visual Pathway Disease

Disorder Of Visual Pathways

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14536	TIMM9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TIMM9	MGD	MGI:1353436
Bos taurus	TIMM9	VGNC	VGNC:55149
Canis familiaris	TIMM9	VGNC	VGNC:49625
Rattus norvegicus	TIMM9	RGD	RGD:621656

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