TIMM10 - translocase of inner mitochondrial membrane 10 Gene

Homo sapiens

Also known as TIM10; TIM10A; TIMM10A

Gene ID: 26519 | Gene type: protein coding

About TIMM10

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,528,464-57,530,754 (from NCBI)

This gene has 3 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in kidney (RPKM 18.4), liver (RPKM 14.8) and 25 other tissues.

Summary

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

TIMM10 Products(1)

mRNA	Protein	Name
NM_012456.3	NP_036588.1	mitochondrial import inner membrane translocase subunit Tim10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables membrane insertase activity	IDA IDA: Inferred from direct assay	16387659	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14726512	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16387659	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	16387659	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein insertion into mitochondrial inner membrane	IDA IDA: Inferred from direct assay	16387659	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TIM22 mitochondrial import inner membrane insertion complex	IPI IPI: Inferred from physical interaction	32901109	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	14726512	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IDA IDA: Inferred from direct assay	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IPI IPI: Inferred from physical interaction	14726512	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIMM10 Protein Structure

zf-Tim10_DDP

0
90 a.a.

Protein Preferred Names

Protein Names

mitochondrial import inner membrane translocase subunit Tim10

translocase of inner mitochondrial membrane 10 homolog

Related Diseases

Diseases

Alias

Mohr-Tranebjaerg Syndrome

Deafness-Dystonia-Optic Neuronopathy Syndrome	Jensen Syndrome
Deafness Dystonia Syndrome	MTS
Dds	Deafness-Dystonia-Optic Atrophy Syndrome
Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency	Opticoacoustic Nerve Atrophy With Dementia
Dystonia-Deafness Syndrome	Ddp
Ddon Syndrome	Mohr-Tranebjærg Syndrome
Deafness Dystonia Optic Atrophy Syndrome	Deafness Dystonia Optic Neuronopathy Syndrome
Dystonia Deafness Syndrome	Ddon
Deafness - Dystonia - Optic Neuronopathy Syndrome	Deafness-Dystonia-Optic Neuronopathy Syndrome
Hearing Loss-Dystonia-Optic Neuronopathy Syndrome	Dfn-1
X-Linked Progressive Deafness Type 1

Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Visual Cortex Disease

Visual Cortex Dysfunction	Visual Cortex Disorder
Visual Cortical Disorder	Disease Of Visual Cortex

Visual Pathway Disease

Disorder Of Visual Pathways

Lymph Node Tuberculosis

King'S Evil	Scrofula
Tuberculous Adenitis	Tuberculous Lymphadenopathy
Tuberculosis, Lymph Node

Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28	SCA28
Ataxia, Spinocerebellar, Type 28

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Cortical Blindness

Blindness, Cortical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14527	TIMM10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TIMM10	VGNC	VGNC:81928
Mus musculus	TIMM10	MGD	MGI:1353429
Canis familiaris	TIMM10	VGNC	VGNC:49618
Bos taurus	TIMM10	VGNC	VGNC:97317
Macaca mulatta	TIMM10	VGNC	VGNC:107651
Rattus norvegicus	TIMM10	RGD	RGD:621741

Name
Email *

	Sorry, but the email address you supplied was invalid.