SRPK3 - SRSF protein kinase 3 Gene

Homo sapiens

Also known as MSSK1; STK23; MSSK-1

Gene ID: 26576 | Gene type: protein coding

About SRPK3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,781,041-153,785,730 (from NCBI)

This gene has 8 transcripts (splice variants), 262 orthologues and 19 paralogues. Biased expression in heart (RPKM 9.9), prostate (RPKM 3.3) and 7 other tissues.

Summary

This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

SRPK3 Products(3)

mRNA	Protein	Name
NM_001170760.2	NP_001164231.1	SRSF protein kinase 3 isoform 2
NM_001170761.2	NP_001164232.1	SRSF protein kinase 3 isoform 3
NM_014370.4	NP_055185.2	SRSF protein kinase 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23602568	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPK3 Protein Structure

Pkinase

0
100
200
300
400
500
567 a.a.

Protein Preferred Names

Protein Names

SRSF protein kinase 3

SFRS protein kinase 3

SRPK3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SRPK3	Q9UPE1	SRPK1	Homo sapiens	Q96SB4	Pull Down	32707033

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SRPK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76659	SRPK3 Protein, Human (sf9, GST)	Q9UPE1-4/NP_001164231.1 (M1-P566)	≥95%

Related Diseases

Diseases

Alias

Tonne-Kalscheuer Syndrome

TOKAS	Mrx61
Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia	Mental Retardation, X-Linked 61
X-Linked Mental Retardation 61

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148518	MSC-1186	Inhibitor	99.42%	Unkown
HY-113831	CLK1/2-IN-3	Inhibitor	/	Unkown
HY-RS13779	SRPK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRPK3	RGD	RGD:727856
Macaca mulatta	SRPK3	VGNC	VGNC:77914
Bos taurus	SRPK3	VGNC	VGNC:35290
Mus musculus	SRPK3	MGD	MGI:1891338
Canis familiaris	SRPK3	VGNC	VGNC:46812
Others	SRPK3	NCBI

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