2. Gene
  3. SRPK1 - SRSF protein kinase 1 Gene

SRPK1 - SRSF protein kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SFRSK1

Gene ID: 6732 | Gene type: protein coding

About SRPK1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,832,966-35,921,098 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 19 paralogues. Broad expression in testis (RPKM 31.4), bone marrow (RPKM 17.2) and 25 other tissues.

Summary

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

SRPK1 Products(1)

mRNA Protein Name
NM_003137.5 NP_003128.3 SRSF protein kinase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
11509566 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
11509566 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9237760 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9237760 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromosome segregation IDA
IDA: Inferred from direct assay
15034300 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11509566 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
12417631 GOA
involved in positive regulation of viral genome replication IDA
IDA: Inferred from direct assay
20498328 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9237760 GOA
involved in regulation of mRNA processing IDA
IDA: Inferred from direct assay
8208298 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
28076779 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11509566 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
28076779 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
28076779 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11509566 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (80 - 225)

Pkinase

Pkinase: Protein kinase domain (489 - 653)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

SRSF protein kinase 1

SFRS protein kinase 1

Related Diseases

Diseases Alias
Denys-Drash Syndrome

Drash Syndrome

DDS

Nephropathy, Wilms Tumor, And Genital Anomalies

Wilms Tumor And Pseudohermaphroditism

Wilms Tumor And Pseudo- Or True Hermaphroditism

Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor

Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor

Wilms Tumor-Dsd Syndrome

Wilms Tumor-Disorder Of Sex Development Syndrome
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117661 SPHINX31 Inhibitor 99.13% Unkown
HY-13949 SRPIN340 Inhibitor 99.97% Unkown
HY-116856 SRPKIN-1 Inhibitor 98.02% Unkown
HY-148518 MSC-1186 Inhibitor 99.42% Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-114653 SRPIN803 Inhibitor 99.17% Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-160586 Srpk1-IN-1 Inhibitor / Unkown
HY-160587 Antiangiogenic agent 5 Inhibitor / Unkown
HY-RS13777 SRPK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRPK1 RGD RGD:1308272
Bos taurus SRPK1 VGNC VGNC:54238
Canis familiaris SRPK1 VGNC VGNC:54365
Felis catus SRPK1 VGNC VGNC:65687
Macaca mulatta SRPK1 VGNC VGNC:103870
Mus musculus SRPK1 MGD MGI:106908