SRPK1 - SRSF protein kinase 1 Gene

Homo sapiens

Also known as SFRSK1

Gene ID: 6732 | Gene type: protein coding

About SRPK1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,832,966-35,921,098 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 19 paralogues. Broad expression in testis (RPKM 31.4), bone marrow (RPKM 17.2) and 25 other tissues.

Summary

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]

SRPK1 Products(1)

mRNA	Protein	Name
NM_003137.5	NP_003128.3	SRSF protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11509566	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	11509566	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9237760	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9237760	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IDA IDA: Inferred from direct assay	15034300	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11509566	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	12417631	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	20498328	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9237760	GOA
involved in regulation of mRNA processing	IDA IDA: Inferred from direct assay	8208298	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	28076779	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11509566	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	28076779	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	28076779	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11509566	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPK1 Protein Structure

Pkinase

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

SRSF protein kinase 1

SFRS protein kinase 1

SRPK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SRPK1	Q96SB4	SREK1	Homo sapiens	Q8WXA9	Pull Down	32707033
Intra	SRPK1	Q96SB4	USP39	Homo sapiens	Q53GS9	Pull Down	32707033
Intra	SRPK1	Q96SB4	USP39	Homo sapiens	Q53GS9	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	SNRNP70	Homo sapiens	P08621	Pull Down	32707033
Intra	SRPK1	Q96SB4	SNRNP70	Homo sapiens	P08621	Protein Kinase Assay	23602568
Cross	SRPK1	Q96SB4	N	SARS-CoV-2	P0DTC9	Protein Kinase Assay	33247108
Intra	SRPK1	Q96SB4	YTHDC1	Homo sapiens	Q96MU7	Anti Tag CoIP	23602568
Intra	SRPK1	Q96SB4	YTHDC1	Homo sapiens	Q96MU7	TAP	23602568
Intra	SRPK1	Q96SB4	LUC7L2	Homo sapiens	Q9Y383	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	LUC7L2	Homo sapiens	Q9Y383	Pull Down	32707033
Intra	SRPK1	Q96SB4	LUC7L2	Homo sapiens	Q9Y383	TAP	23602568
Intra	SRPK1	Q96SB4	TP53	Homo sapiens	P04637	Pull Down	21130767
Intra	SRPK1	Q96SB4	SRSF3	Homo sapiens	P84103	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	SNRPD3	Homo sapiens	P62318	Crosslink	30021884
Intra	SRPK1	Q96SB4	RBM39	Homo sapiens	Q14498	TAP	23602568
Intra	SRPK1	Q96SB4	RBM39	Homo sapiens	Q14498	Pull Down	32707033
Intra	SRPK1	Q96SB4	RNPS1	Homo sapiens	Q15287	Pull Down	32707033
Intra	SRPK1	Q96SB4	RNPS1	Homo sapiens	Q15287	BiFC	23602568
Intra	SRPK1	Q96SB4	SRSF7	Homo sapiens	Q16629	TAP	23602568
Intra	SRPK1	Q96SB4	SRSF1	Homo sapiens	Q07955	Pull Down	10196197
Intra	SRPK1	Q96SB4	RBM8A	Homo sapiens	Q9Y5S9	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	RBM8A	Homo sapiens	Q9Y5S9	TAP	23602568
Intra	SRPK1	Q96SB4	LUC7L	Homo sapiens	Q9NQ29	TAP	23602568
Intra	SRPK1	Q96SB4	DGCR8	Homo sapiens	Q8WYQ5	TAP	23602568
Intra	SRPK1	Q96SB4	U2AF1	Homo sapiens	Q01081	TAP	23602568
Intra	SRPK1	Q96SB4	SRSF8	Homo sapiens	Q9BRL6	TAP	23602568
Intra	SRPK1	Q96SB4	SRPK3	Homo sapiens	Q9UPE1	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	SRPK3	Homo sapiens	Q9UPE1	TAP	23602568
Intra	SRPK1	Q96SB4	ZRSR2	Homo sapiens	Q15696	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	PTK2	Homo sapiens	Q05397	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	PRPF38A	Homo sapiens	Q8NAV1	Pull Down	32707033
Intra	SRPK1	Q96SB4	PRPF38A	Homo sapiens	Q8NAV1	Y2H	22365833
Cross	SRPK1	Q96SB4	a7y3z3_hpv16	Human papillomavirus	A7Y3Z3	CoIP	17360743
Cross	SRPK1	Q96SB4	a7y3z3_hpv16	Human papillomavirus	A7Y3Z3	Pull Down	17360743
Cross	SRPK1	Q96SB4	a7y3z3_hpv16	Human papillomavirus	A7Y3Z3	Fluorescence	17360743
Intra	SRPK1	Q96SB4	KRR1	Homo sapiens	Q13601	Protein Kinase Assay	23602568
Intra	SRPK1	Q96SB4	KRR1	Homo sapiens	Q13601	Pull Down	32707033
Intra	SRPK1	Q96SB4	SRSF6	Homo sapiens	Q13247	Protein Kinase Assay	23602568
Cross	SRPK1	Q96SB4	Safb	Rattus norvegicus	O88453	Pull Down	11509566

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Denys-Drash Syndrome

Drash Syndrome	DDS
Nephropathy, Wilms Tumor, And Genital Anomalies	Wilms Tumor And Pseudohermaphroditism
Wilms Tumor And Pseudo- Or True Hermaphroditism	Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor
Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor	Wilms Tumor-Dsd Syndrome
Wilms Tumor-Disorder Of Sex Development Syndrome

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117661	SPHINX31	Inhibitor	99.13%	Unkown
HY-13949	SRPIN340	Inhibitor	99.97%	Unkown
HY-116856	SRPKIN-1	Inhibitor	98.02%	Unkown
HY-148518	MSC-1186	Inhibitor	99.42%	Unkown
HY-114653	SRPIN803	Inhibitor	99.17%	Unkown
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-113831	CLK1/2-IN-3	Inhibitor	/	Unkown
HY-160586	Srpk1-IN-1	Inhibitor	/	Unkown
HY-160587	Antiangiogenic agent 5	Inhibitor	/	Unkown
HY-RS13777	SRPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRPK1	RGD	RGD:1308272
Bos taurus	SRPK1	VGNC	VGNC:54238
Canis familiaris	SRPK1	VGNC	VGNC:54365
Felis catus	SRPK1	VGNC	VGNC:65687
Macaca mulatta	SRPK1	VGNC	VGNC:103870
Mus musculus	SRPK1	MGD	MGI:106908

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