PCOLCE2 - procollagen C-endopeptidase enhancer 2 Gene

Homo sapiens

Also known as PCPE2

Gene ID: 26577 | Gene type: protein coding

About PCOLCE2

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:142,817,874-142,889,083 (from NCBI)

This gene has 11 transcripts (splice variants), 214 orthologues and 35 paralogues. Biased expression in fat (RPKM 75.7), heart (RPKM 31.8) and 9 other tissues.

Summary

Enables collagen binding activity; heparin binding activity; and peptidase activator activity. Predicted to be involved in positive regulation of peptidase activity. Predicted to act upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PCOLCE2 Products(1)

mRNA	Protein	Name
NM_013363.4	NP_037495.1	procollagen C-endopeptidase enhancer 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	12393877	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	12393877	GOA
enables peptidase activator activity	IDA IDA: Inferred from direct assay	12393877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCOLCE2 Protein Structure

CUB

NTR

0
100
200
300
415 a.a.

Protein Preferred Names

Protein Names

procollagen C-endopeptidase enhancer 2

procollagen C-proteinase enhancer 2

PCOLCE2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PCOLCE2	Q9UKZ9	ZWINT	Homo sapiens	O95229	Anti Tag CoIP	28514442
Intra	PCOLCE2	Q9UKZ9	ZWINT	Homo sapiens	O95229	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pulmonary Subvalvular Stenosis

Pulmonary Infundibular Stenosis	Congenital Infundibular Stenosis
Infundibular Pulmonic Stenosis	Infundibular Pulmonic Stenosis, Congenital
Subvalvular Pulmonic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10166	PCOLCE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PCOLCE2	VGNC	VGNC:32643
Rattus norvegicus	PCOLCE2	RGD	RGD:1595195
Felis catus	PCOLCE2	VGNC	VGNC:68730
Macaca mulatta	PCOLCE2	VGNC	VGNC:75783
Mus musculus	PCOLCE2	MGD	MGI:1923727
Canis familiaris	PCOLCE2	VGNC	VGNC:44317

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