ADGRF1 - adhesion G protein-coupled receptor F1 Gene

Homo sapiens

Also known as PGR19; GPR110; KPG_012; hGPCR36

Gene ID: 266977 | Gene type: protein coding

About ADGRF1

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,997,708-47,042,332 (from NCBI)

This gene has 13 transcripts (splice variants), 158 orthologues and 42 paralogues. Biased expression in urinary bladder (RPKM 9.0), kidney (RPKM 6.7) and 5 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADGRF1 Products(2)

mRNA	Protein	Name
NM_025048.4	NP_079324.2	adhesion G-protein coupled receptor F1 isoform 2 precursor
NM_153840.4	NP_722582.2	adhesion G-protein coupled receptor F1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	34110646	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRF1 Protein Structure

SEA

GPS

7tm_2

0
200
400
600
800
910 a.a.

Protein Preferred Names

Protein Names

adhesion G-protein coupled receptor F1

G protein-coupled receptor 110

ADGRF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ADGRF1	Q5T601	GNAQ	Homo sapiens	P50148	Anti Bait CoIP	34110646

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Usher Syndrome, Type Iic

Usher Syndrome Type 2c	USH2C
Usher Syndrome, Type 2c	Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic
Usher Syndrome Type Iic	Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic
Usher Syndrome 2c	Usher'S Syndrome Type 2c
Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Adie Pupil

Adie Syndrome	Holmes-Adie Syndrome
Poorly Reacting Pupils	Adie'S Pupil Or Syndrome
Adie'S Pupil Syndrome	Adie'S Syndrome
Adie'S Pupil	Has
Tonic, Sluggishly Reacting Pupil And Hypoactive Or Absent Tendon Reflexes	Tonic Pupil-Tendon Areflexia Syndrome
ADIEP	Tonic Pupil

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Usher Syndrome Type 2

Ush2	Usher Syndrome Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00352	ADGRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADGRF1	VGNC	VGNC:59631
Macaca mulatta	ADGRF1	VGNC	VGNC:81007
Bos taurus	ADGRF1	VGNC	VGNC:25661
Canis familiaris	ADGRF1	VGNC	VGNC:37638
Rattus norvegicus	ADGRF1	RGD	RGD:1310285
Mus musculus	ADGRF1	MGD	MGI:1924846

Name
Email *

	Sorry, but the email address you supplied was invalid.