GFER - growth factor, augmenter of liver regeneration Gene

Homo sapiens

Also known as ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1; MMCHD; MPMCD

Gene ID: 2671 | Gene type: protein coding

About GFER

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,984,193-1,987,749 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and is associated with 4 phenotypes. Ubiquitous expression in small intestine (RPKM 7.8), duodenum (RPKM 7.7) and 25 other tissues.

Summary

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for Oxidative Phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

GFER Products(1)

mRNA	Protein	Name
NM_005262.3	NP_005253.3	FAD-linked sulfhydryl oxidase ALR

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	22224850	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12681488	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	22224850	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	23676665	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFER Protein Structure

Evr1_Alr

0
100
205 a.a.

Protein Preferred Names

Protein Names

FAD-linked sulfhydryl oxidase ALR

ERV1 homolog

Recombinant GFER Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70953	GFER Protein, Human (His)	P55789-2 (M1-D125)	≥95%
HY-P74126	GFER Protein, Human (HEK293, His)	P55789-2 (M1-D125)	≥95%

Related Diseases

Diseases

Alias

Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay

Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay	Congenital Cataract-Progressive Muscular Hypotonia-Hearing Loss-Developmental Delay Syndrome
MPMCD	Myopathy With Cataract And Combined Respiratory Chain Deficiency
Mitochondrial Complex Deficiency, Combined	Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And
Myopathy With Cataract And Combined Respiratory-Chain Deficiency	Congenital Cataract-Progressive Muscular Hypotonia-Deafness-Developmental Delay Syndrome
Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss And Developmental Delay	Combined Mitochondrial Complex Deficiency

Mitochondrial Disease

Mitochondrial Diseases

Mitochondrial Disorder

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Myopathy

Muscular Diseases

Myopathies

Budd-Chiari Syndrome

Hepatic Vein Thrombosis	Chiari Syndrome
BDCHS	Membranous Obstruction Of The Inferior Vena Cava
Budd-Chiari Syndrome, Somatic	Movc
Budd-Chiari Syndrome, Susceptibility To, Somatic	Budd-Chiari Syndrome, Susceptibility To
Membranous Obstruction Of Inferior Vena Cava	Hepatic Vein Block
Obstruction Of Hepatic Veins	Hepatic Vein Obstruction
Hepatic Venous Block

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05377	GFER Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GFER	VGNC	VGNC:62521
Rattus norvegicus	GFER	RGD	RGD:61845
Bos taurus	GFER	VGNC	VGNC:29324
Mus musculus	GFER	MGD	MGI:107757
Macaca mulatta	GFER	VGNC	VGNC:104729
Others	GFER	NCBI

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