2. Gene
  3. GFER - growth factor, augmenter of liver regeneration Gene

GFER - growth factor, augmenter of liver regeneration Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1; MMCHD; MPMCD

Gene ID: 2671 | Gene type: protein coding

About GFER

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,984,193-1,987,749 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and is associated with 4 phenotypes. Ubiquitous expression in small intestine (RPKM 7.8), duodenum (RPKM 7.7) and 25 other tissues.

Summary

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for Oxidative Phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

GFER Products(1)

mRNA Protein Name
NM_005262.3 NP_005253.3 FAD-linked sulfhydryl oxidase ALR
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
22224850 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12681488 GOA
enables protein-disulfide reductase activity IDA
IDA: Inferred from direct assay
22224850 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
23676665 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFER Protein Structure

Evr1_Alr

Evr1_Alr: Erv1 / Alr family (105 - 196)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

FAD-linked sulfhydryl oxidase ALR

ERV1 homolog

GFER Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
GFER P55789 P0DTD1-PRO_0000449628 SARS-CoV-2 P0DTD1-PRO_0000449628
Y2H Array
36217030
Intra
GFER P55789 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
25416956
Intra
GFER P55789 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GFER Proteins

Cat. No. Product Name Accession Purity
HY-P70953 GFER Protein, Human (His) P55789-2 (M1-D125) ≥95%
HY-P74126 GFER Protein, Human (HEK293, His) P55789-2 (M1-D125) ≥95%

Related Diseases

Diseases Alias
Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay

Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay

Congenital Cataract-Progressive Muscular Hypotonia-Hearing Loss-Developmental Delay Syndrome

MPMCD

Myopathy With Cataract And Combined Respiratory Chain Deficiency

Mitochondrial Complex Deficiency, Combined

Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And

Myopathy With Cataract And Combined Respiratory-Chain Deficiency

Congenital Cataract-Progressive Muscular Hypotonia-Deafness-Developmental Delay Syndrome

Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss And Developmental Delay

Combined Mitochondrial Complex Deficiency
Mitochondrial Disease

Mitochondrial Diseases

Mitochondrial Disorder
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Myopathy

Muscular Diseases

Myopathies
Budd-Chiari Syndrome

Hepatic Vein Thrombosis

Chiari Syndrome

BDCHS

Membranous Obstruction Of The Inferior Vena Cava

Budd-Chiari Syndrome, Somatic

Movc

Budd-Chiari Syndrome, Susceptibility To, Somatic

Budd-Chiari Syndrome, Susceptibility To

Membranous Obstruction Of Inferior Vena Cava

Hepatic Vein Block

Obstruction Of Hepatic Veins

Hepatic Vein Obstruction

Hepatic Venous Block
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05377 GFER Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GFER VGNC VGNC:62521
Rattus norvegicus GFER RGD RGD:61845
Bos taurus GFER VGNC VGNC:29324
Mus musculus GFER MGD MGI:107757
Macaca mulatta GFER VGNC VGNC:104729
Others GFER NCBI