2. Gene
  3. RPS6KC1 - ribosomal protein S6 kinase C1 Gene

RPS6KC1 - ribosomal protein S6 kinase C1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RSKL1; RPK118; S6PKh1; humS6PKh1; S6K-delta-1

Gene ID: 26750 | Gene type: protein coding

About RPS6KC1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:213,051,241-213,862,735 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 12.3), brain (RPKM 7.8) and 25 other tissues.

Summary

Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]

RPS6KC1 Products(31)

mRNA Protein Name
NM_001136138.4 NP_001129610.1 ribosomal protein S6 kinase delta-1 isoform b
NM_001287218.3 NP_001274147.1 ribosomal protein S6 kinase delta-1 isoform c
NM_001287219.3 NP_001274148.1 ribosomal protein S6 kinase delta-1 isoform c
NM_001287220.3 NP_001274149.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001287221.3 NP_001274150.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349646.2 NP_001336575.1 ribosomal protein S6 kinase delta-1 isoform f
NM_001349647.2 NP_001336576.1 ribosomal protein S6 kinase delta-1 isoform g
NM_001349648.2 NP_001336577.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349649.2 NP_001336578.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349650.2 NP_001336579.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349651.2 NP_001336580.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349652.2 NP_001336581.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349653.2 NP_001336582.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349654.2 NP_001336583.1 ribosomal protein S6 kinase delta-1 isoform c
NM_001349657.2 NP_001336586.1 ribosomal protein S6 kinase delta-1 isoform h
NM_001349658.2 NP_001336587.1 ribosomal protein S6 kinase delta-1 isoform h
NM_001349659.2 NP_001336588.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349660.2 NP_001336589.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349661.2 NP_001336590.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349662.2 NP_001336591.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349663.2 NP_001336592.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349664.2 NP_001336593.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349665.2 NP_001336594.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349666.2 NP_001336595.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349667.2 NP_001336596.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349668.2 NP_001336597.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349669.2 NP_001336598.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349670.2 NP_001336599.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349671.2 NP_001336600.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349672.2 NP_001336601.1 ribosomal protein S6 kinase delta-1 isoform j
NM_012424.6 NP_036556.2 ribosomal protein S6 kinase delta-1 isoform a
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15750338 GOA
Cellular Component GO Annotation Evidence Reference Source
located in early endosome IDA
IDA: Inferred from direct assay
15750338 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KC1 Protein Structure

PX

PX: PX domain (16 - 126)

MIT

MIT: MIT (microtubule interacting and transport) domain (239 - 305)

Pkinase

Pkinase: Protein kinase domain (881 - 1056)

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  • 1000
  • 1066 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase delta-1

52 kDa ribosomal protein S6 kinase

RPS6KC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RPS6KC1 Q96S38 VDR Homo sapiens P11473-2
Y2H Prey Pooling
32296183
Intra
RPS6KC1 Q96S38 VDR Homo sapiens P11473-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Periventricular Leukomalacia

Leukomalacia, Periventricular

Pvl

Leukomalacia Periventricular
Hypotonia
Charcot-Marie-Tooth Disease, Axonal, Type 2n

Charcot-Marie-Tooth Disease Axonal Type 2n

CMT2N

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2n

Charcot-Marie-Tooth Neuropathy Axonal Type 2n

Charcot-Marie-Tooth Neuropathy, Axonal, Type 2n

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2n

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2n

Charcot-Marie-Tooth Disease 2n

Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2n

Charcot-Marie-Tooth Disease, Type 2n
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12268 RPS6KC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPS6KC1 MGD MGI:2443419
Rattus norvegicus RPS6KC1 RGD RGD:1306578
Macaca mulatta RPS6KC1 VGNC VGNC:76935
Canis familiaris RPS6KC1 VGNC VGNC:45746
Felis catus RPS6KC1 VGNC VGNC:97613
Bos taurus RPS6KC1 VGNC VGNC:34148