GFRA3 - GDNF family receptor alpha 3 Gene

Homo sapiens

Also known as GDNFR3

Gene ID: 2676 | Gene type: protein coding

About GFRA3

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,252,380-138,274,621 (from NCBI)

This gene has 2 transcripts (splice variants), 260 orthologues and 4 paralogues. Broad expression in testis (RPKM 2.5), colon (RPKM 2.3) and 18 other tissues.

Summary

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF Receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, Artemin. [provided by RefSeq, Jul 2008]

GFRA3 Products(1)

mRNA	Protein	Name
NM_001496.4	NP_001487.2	GDNF family receptor alpha-3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glial cell-derived neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	31535977	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16765900	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glial cell-derived neurotrophic factor receptor signaling pathway	IDA IDA: Inferred from direct assay	31535977	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	9576965	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFRA3 Protein Structure

GDNF

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

GDNF family receptor alpha-3

GDNF receptor alpha-3

Recombinant GFRA3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77372	GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc)	O60609-1/NP_001487.2 (D32-W382)	≥95%
HY-P77373	GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His)	O60609-1/NP_001487.2 (D32-W382)	≥95%

Related Diseases

Diseases

Alias

Postsurgical Hypothyroidism

Postoperative Hypothyroidism

Post-Surgical Hypothyroidism

Retinitis Pigmentosa 19

RP19	Retinitis Pigmentosa-19
Retinitis Pigmentosa, Type 19

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05388	GFRA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99748	Nadecnemab	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GFRA3	VGNC	VGNC:62531
Macaca mulatta	GFRA3	VGNC	VGNC:72919
Mus musculus	GFRA3	MGD	MGI:1201403
Bos taurus	GFRA3	VGNC	VGNC:29334
Canis familiaris	GFRA3	VGNC	VGNC:41191
Rattus norvegicus	GFRA3	RGD	RGD:620502
Others	GFRA3	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.