FOXB1 - forkhead box B1 Gene

Homo sapiens

Also known as FKH5; HFKH-5

Gene ID: 27023 | Gene type: protein coding

About FOXB1

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:60,004,311-60,007,444 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues and 42 paralogues. Low expression observed in reference dataset.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including mammary gland development; nervous system development; and visual learning. Predicted to act upstream of or within spinal cord development; thalamus development; and urogenital system development. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

FOXB1 Products(1)

mRNA	Protein	Name
NM_012182.3	NP_036314.2	forkhead box protein B1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXB1 Protein Structure

Forkhead

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

forkhead box protein B1

transcription factor FKH-5

FOXB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXB1	Q99853	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	FOXB1	Q99853	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	FOXB1	Q99853	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	FOXB1	Q99853	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Wernicke-Korsakoff Syndrome

Korsakoff Syndrome	Transketolase Defect
Korsakoff'S Syndrome	Alcohol-Induced Encephalopathy
Korsakoff'S Psychosis	Korsakov Psychosis
Korsakov'S Psychosis	Alcohol Induced Encephalopathy
Korsakoff Disease	Korsakoff Psychosis

Thiamine Deficiency Disease

Septooptic Dysplasia

Septo-Optic Dysplasia	De Morsier Syndrome
Growth Hormone Deficiency With Pituitary Anomalies	SOD
Pituitary Hormone Deficiency, Combined, 5	Septo-Optic Dysplasia Spectrum
Septo-Optic Dysplasia With Growth Hormone Deficiency	Pituitary Hormone Deficiency, Combined 5
Hypopituitarism And Septooptic 'Dysplasia'	GHDPA
CPHD5	Dysplasia, Septo-Optic
Kallmann Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05039	FOXB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FOXB1	VGNC	VGNC:29080
Macaca mulatta	FOXB1	VGNC	VGNC:72692
Felis catus	FOXB1	VGNC	VGNC:62331
Rattus norvegicus	FOXB1	RGD	RGD:1305217
Mus musculus	FOXB1	MGD	MGI:1927549
Canis familiaris	FOXB1	VGNC	VGNC:40946

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