GHITM - growth hormone inducible transmembrane protein Gene

Homo sapiens

Also known as DERP2; MICS1; My021; PTD010; TMBIM5; HSPC282

Gene ID: 27069 | Gene type: protein coding

About GHITM

Cytogenetic location: 10q23.1 Genomic coordinates (GRCh38): 10:84,139,509-84,153,568 (from NCBI)

This gene has 13 transcripts (splice variants), 230 orthologues and 5 paralogues. Ubiquitous expression in heart (RPKM 139.5), kidney (RPKM 133.1) and 25 other tissues.

Summary

Involved in inner mitochondrial membrane organization and negative regulation of release of cytochrome c from mitochondria. Located in mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

GHITM Products(1)

mRNA	Protein	Name
NM_014394.3	NP_055209.2	growth hormone-inducible transmembrane protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium:proton antiporter activity	IMP IMP: Inferred from mutant phenotype	36321428	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium export from the mitochondrion	IMP IMP: Inferred from mutant phenotype	35912435	GOA
involved in calcium ion transport	IMP IMP: Inferred from mutant phenotype	36321428	GOA
involved in inner mitochondrial membrane organization	IMP IMP: Inferred from mutant phenotype	18417609	GOA
involved in mitochondrial calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	35912435	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	18417609	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	18417609	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GHITM Protein Structure

BaxI_1

Bax1-I

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

growth hormone-inducible transmembrane protein

dermal papilla-derived protein 2

GHITM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GHITM	Q9H3K2	TMEM242	Homo sapiens	Q9NWH2	Y2H Array	32296183
Intra	GHITM	Q9H3K2	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	GHITM	Q9H3K2	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	GHITM	Q9H3K2	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	GHITM	Q9H3K2	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	GHITM	Q9H3K2	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	GHITM	Q9H3K2	JSRP1	Homo sapiens	Q96MG2	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	JSRP1	Homo sapiens	Q96MG2	Y2H Array	32296183
Intra	GHITM	Q9H3K2	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	GHITM	Q9H3K2	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	GHITM	Q9H3K2	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	GHITM	Q9H3K2	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Cross	GHITM	Q9H3K2	orf9c_sars2	SARS-CoV-2	P0DTD3	Y2H Array	36217030
Intra	GHITM	Q9H3K2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	GHITM	Q9H3K2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	GHITM	Q9H3K2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Persistent Moderate Asthma

Persistent Mild Asthma

Inflammatory Bowel Disease 20

IBD20

Celery Allergy

Pollen Allergy

Hay Fever

Vegetable Allergy

Shrimp Allergy

Crustacean Allergy

Nasal Cavity Disease

Disorder Of Nasal Cavity

Respiratory Allergy

Airway Allergy

Thunderstorm Triggered Asthma

Thunderstorm Asthma

Thunderstorm Related Asthma

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Apple Allergy

Malus Domestica Fruit Allergy

Wheat Allergy

Wheat Allergic Reaction	Wheat Hypersensitivity
Allergy To Wheat	Allergy Wheat

Chronic Rhinitis

Rhinitis - Chronic	Chronic Rhinitis Nos
Rhinitis	Rhinitis Nos

Latex Allergy

Fruit Allergy

Allergy To Fruit

Legume Allergy

Fabaceae Allergy

Chronic Asthma

Peanut Allergy

Allergy To Peanuts	Peanut Allergic Reaction
Allergies Peanut	Peanut Hypersensitivity

Egg Allergy

Allergy To Eggs	Allergies Egg
Egg Hypersensitivity

Occupational Asthma

Environmental Induced Asthma

Irritant Asthma

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05411	GHITM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GHITM	VGNC	VGNC:41205
Macaca mulatta	GHITM	VGNC	VGNC:72735
Bos taurus	GHITM	VGNC	VGNC:29348
Rattus norvegicus	GHITM	RGD	RGD:1359301
Mus musculus	GHITM	MGD	MGI:1913342
Felis catus	GHITM	VGNC	VGNC:62543

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