2. Gene
  3. DKK3 - dickkopf WNT signaling pathway inhibitor 3 Gene

DKK3 - dickkopf WNT signaling pathway inhibitor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RIG; CRRL; REIC

Gene ID: 27122 | Gene type: protein coding

About DKK3

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,963,036-12,009,745 (from NCBI)

This gene has 17 transcripts (splice variants) and 266 orthologues. Biased expression in heart (RPKM 451.8), brain (RPKM 155.8) and 7 other tissues.

Summary

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of Cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

DKK3 Products(4)

mRNA Protein Name
NM_001018057.2 NP_001018067.1 dickkopf-related protein 3 isoform 1 precursor
NM_001330220.3 NP_001317149.1 dickkopf-related protein 3 isoform 2 precursor
NM_013253.5 NP_037385.2 dickkopf-related protein 3 isoform 1 precursor
NM_015881.6 NP_056965.3 dickkopf-related protein 3 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
12844346 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16981135 GOA
involved in negative regulation of aldosterone biosynthetic process IDA
IDA: Inferred from direct assay
16981135 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
12857724 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
23538390 GOA
involved in negative regulation of cortisol biosynthetic process IDA
IDA: Inferred from direct assay
16981135 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DKK3 Protein Structure

Dickkopf_N

Dickkopf_N: Dickkopf N-terminal cysteine-rich region (146 - 197)

  • 0
  • 100
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  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

dickkopf-related protein 3

RIG-like 5-6

Recombinant DKK3 Proteins

Cat. No. Product Name Accession Purity
HY-P7812 DKK-3 Protein, Human (HEK293, His) Q9UBP4 (A22-I350) ≥95%
HY-P77640 DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi) Q9UBP4 (P23-I350) ≥95%
HY-P78681 DKK-3 Protein, Human (R335G, HEK293, His) Q9UBP4 (A22-I350, R335G) ≥95%

Related Diseases

Diseases Alias
Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease

Isolated Polycystic Liver Disease

Pcld

Congenital Cystic Liver Disease

Congenital Hepatic Cyst

Fibrocystic Liver Disease

Isolated Autosomal Dominant Polycystic Liver Disease

Adpcld

Liver Disease, Polycystic

Multiple Cysts Of Liver

Pld - [Polycystic Liver Disease]

Polycystic Liver Disorder

Polycystic Liver

Congenital Polycystic Disease Of Liver

Congenital Polycystic Liver Disease
Ventricular Tachycardia, Catecholaminergic Polymorphic, 4

Catecholaminergic Polymorphic Ventricular Tachycardia 4

CPVT4

Bidirectional Tachycardia

Stress-Induced Polymorphic Ventricular Tachycardia

Cvpt4

Double Tachycardia Induced By Catecholamines

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Paroxysmal Ventricular Fibrillation

Syncopal Paroxysmal Tachycardia

Syncopal Tachyarythmia

Vtsip

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 4

Multifocal Pvcs

Multifocal Premature Ventricular Beats

Paroxysmal Familial Ventricular Fibrillation

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Witkop Syndrome

Tooth And Nail Syndrome

Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome

Tns

Ectodermal Dysplasia 3, Witkop Type

ECTD3

Ectodermal Dysplasia 3, Tooth/Nail Type

Tooth-And-Nail Syndrome

Dysplasia Of Nails With Hypodontia

Nail Dysplasia With Hypodontia

Witkop'S Syndrome

Hypodontia - Dysplasia Of Nails

Hypodontia-Dysplasia Of Nails Syndrome

Hypodontia-Nail Dysgenesis Syndrome

Hypodontia-Nail Dysgenesis
Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

Catecholaminergic Polymorphic Ventricular Tachycardia 3

CPVT3

Cvpt3

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03789 DKK3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W107409 Meridianin C / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DKK3 VGNC VGNC:71804
Bos taurus DKK3 VGNC VGNC:28081
Felis catus DKK3 VGNC VGNC:61506
Canis familiaris DKK3 VGNC VGNC:39971
Rattus norvegicus DKK3 RGD RGD:621846
Mus musculus DKK3 MGD MGI:1354952
Others DKK3 NCBI