DKK3 - dickkopf WNT signaling pathway inhibitor 3 Gene

Homo sapiens

Also known as RIG; CRRL; REIC

Gene ID: 27122 | Gene type: protein coding

About DKK3

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:11,963,036-12,009,745 (from NCBI)

This gene has 17 transcripts (splice variants) and 266 orthologues. Biased expression in heart (RPKM 451.8), brain (RPKM 155.8) and 7 other tissues.

Summary

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of Cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

DKK3 Products(4)

mRNA	Protein	Name
NM_001018057.2	NP_001018067.1	dickkopf-related protein 3 isoform 1 precursor
NM_001330220.3	NP_001317149.1	dickkopf-related protein 3 isoform 2 precursor
NM_013253.5	NP_037385.2	dickkopf-related protein 3 isoform 1 precursor
NM_015881.6	NP_056965.3	dickkopf-related protein 3 isoform 1 precursor

DKK3 Protein Structure

Dickkopf_N

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

dickkopf-related protein 3

RIG-like 5-6

Recombinant DKK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7812	DKK-3 Protein, Human (HEK293, His)	Q9UBP4 (A22-I350)	≥95%
HY-P77640	DKK-3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9UBP4 (P23-I350)	≥95%
HY-P78681	DKK-3 Protein, Human (R335G, HEK293, His)	Q9UBP4 (A22-I350, R335G)	≥95%

Related Diseases

Diseases

Alias

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Ventricular Tachycardia, Catecholaminergic Polymorphic, 4

Catecholaminergic Polymorphic Ventricular Tachycardia 4	CPVT4
Bidirectional Tachycardia	Stress-Induced Polymorphic Ventricular Tachycardia
Cvpt4	Double Tachycardia Induced By Catecholamines
Malignant Paroxysmal Ventricular Tachycardia	Multifocal Ventricular Premature Beats
Paroxysmal Ventricular Fibrillation	Syncopal Paroxysmal Tachycardia
Syncopal Tachyarythmia	Vtsip
Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 4	Multifocal Pvcs
Multifocal Premature Ventricular Beats	Paroxysmal Familial Ventricular Fibrillation
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

Witkop Syndrome

Tooth And Nail Syndrome	Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome
Tns	Ectodermal Dysplasia 3, Witkop Type
ECTD3	Ectodermal Dysplasia 3, Tooth/Nail Type
Tooth-And-Nail Syndrome	Dysplasia Of Nails With Hypodontia
Nail Dysplasia With Hypodontia	Witkop'S Syndrome
Hypodontia - Dysplasia Of Nails	Hypodontia-Dysplasia Of Nails Syndrome
Hypodontia-Nail Dysgenesis Syndrome	Hypodontia-Nail Dysgenesis

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

Catecholaminergic Polymorphic Ventricular Tachycardia 3	CPVT3
Cvpt3	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03789	DKK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W107409	Meridianin C		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DKK3	VGNC	VGNC:71804
Bos taurus	DKK3	VGNC	VGNC:28081
Felis catus	DKK3	VGNC	VGNC:61506
Canis familiaris	DKK3	VGNC	VGNC:39971
Rattus norvegicus	DKK3	RGD	RGD:621846
Mus musculus	DKK3	MGD	MGI:1354952
Others	DKK3	NCBI

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