2. Gene
  3. SIGLEC9 - sialic acid binding Ig like lectin 9 Gene

SIGLEC9 - sialic acid binding Ig like lectin 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CD329; CDw329; FOAP-9; siglec-9; OBBP-LIKE

Gene ID: 27180 | Gene type: protein coding

About SIGLEC9

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,119,778-51,136,263 (from NCBI)

This gene has 3 transcripts (splice variants), 84 orthologues and 16 paralogues. Broad expression in appendix (RPKM 3.6), spleen (RPKM 2.9) and 15 other tissues.

Summary

Predicted to enable monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis, engulfment. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGLEC9 Products(2)

mRNA Protein Name
NM_001198558.1 NP_001185487.1 sialic acid-binding Ig-like lectin 9 isoform 1 precursor
NM_014441.3 NP_055256.1 sialic acid-binding Ig-like lectin 9 isoform 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25187624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC9 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (26 - 127)

Ig_3

Ig_3: Immunoglobulin domain (151 - 216)

Ig_2

Ig_2: Immunoglobulin domain (260 - 335)

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  • 463 a.a.
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 9

protein FOAP-9

SIGLEC9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SIGLEC9 Q9Y336 TLR4 Homo sapiens O00206
ELISA
25187624
Intra
SIGLEC9 Q9Y336 NCS1 Homo sapiens P62166
Y2H Array
32296183
Intra
SIGLEC9 Q9Y336 NCS1 Homo sapiens P62166
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGLEC9 Proteins

Cat. No. Product Name Accession Purity
HY-P70739 Siglec-9 Protein, Human (HEK293, His) AAH35365.2 (Q18-G348) ≥95%
HY-P78039 Siglec-9 Protein, Human (HEK293, Fc) Q9Y336 (Q18-G348) ≥95%
HY-P78040 Siglec-9 Protein, Human (HEK293, His-Avi) Q9Y336-1 (Q18-G348) ≥95%
HY-P701040 Siglec-9 Protein, Human (Biotinylated, HEK293, His-Avi) Q9Y336-1 (Q18-G348) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12907 SIGLEC9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIGLEC9 MGD MGI:1932475