2. Gene
  3. NCS1 - neuronal calcium sensor 1 Gene

NCS1 - neuronal calcium sensor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FLUP; FREQ

Gene ID: 23413 | Gene type: protein coding

About NCS1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:130,172,404-130,237,303 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 14 paralogues. Biased expression in brain (RPKM 60.4), esophagus (RPKM 14.4) and 11 other tissues.

Summary

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for Calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCS1 Products(2)

mRNA Protein Name
NM_001128826.2 NP_001122298.1 neuronal calcium sensor 1 isoform 2
NM_014286.4 NP_055101.2 neuronal calcium sensor 1 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12783849 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12783849 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12783849 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCS1 Protein Structure

EF-hand_1

EF-hand_1: EF hand (68 - 90)

EF-hand_7

EF-hand_7: EF-hand domain pair (100 - 171)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

neuronal calcium sensor 1

frequenin homolog

NCS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NCS1 P62166 NBL1 Homo sapiens P41271
Validated Y2H
25416956
Intra
NCS1 P62166 CEP89 Homo sapiens Q96ST8-3
Validated Y2H
32296183
Intra
NCS1 P62166 CEP89 Homo sapiens Q96ST8-3
MAPPIT
32296183
Intra
NCS1 P62166 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 CTAG1A Homo sapiens P78358
Validated Y2H
32296183
Intra
NCS1 P62166 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
NCS1 P62166 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra
NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Validated Y2H
32296183
Intra
NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Y2H Array
32296183
Intra
NCS1 P62166 SFTPA2 Homo sapiens Q8IWL1
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 LY6G6D Homo sapiens O95868
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 LY6G6D Homo sapiens O95868
Y2H Array
32296183
Intra
NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Validated Y2H
32296183
Intra
NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
Intra
NCS1 P62166 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 SIGLEC9 Homo sapiens Q9Y336
Validated Y2H
32296183
Intra
NCS1 P62166 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra
NCS1 P62166 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 CREM Homo sapiens Q03060-25
Validated Y2H
32296183
Intra
NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
NCS1 P62166 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
NCS1 P62166 RNASEH1 Homo sapiens O60930
Y2H Array
32296183
Intra
NCS1 P62166 RNASEH1 Homo sapiens O60930
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Y2H Array
32296183
Intra
NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 PRDM4 Homo sapiens Q9UKN5
Validated Y2H
32296183
Intra
NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra
NCS1 P62166 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
32296183
Intra
NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Validated Y2H
32296183
Intra
NCS1 P62166 SPRED2 Homo sapiens Q7Z698
Y2H Array
32296183
Intra
NCS1 P62166 SPP1 Homo sapiens P10451
Y2H Array
32296183
Intra
NCS1 P62166 SPP1 Homo sapiens P10451
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Validated Y2H
25416956
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Array
25416956
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Pooling
16189514
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
NCS1 P62166 DTX2 Homo sapiens Q86UW9
Y2H
21516116
Intra
NCS1 P62166 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Wolfram Syndrome 2

WFS2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N2037C (S)-Higenamine hydrobromide ≥97.0% Unkown
HY-122579 IGS-1.76 Inhibitor 98.57% Unkown
HY-W012653 4'-Methylacetophenone 98.71% Unkown
HY-N2037B (S)-Higenamine / Unkown
HY-RS09102 NCS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-121503 FD44 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NCS1 RGD RGD:68417
Canis familiaris NCS1 VGNC VGNC:43667
Bos taurus NCS1 VGNC VGNC:31928
Felis catus NCS1 VGNC VGNC:63744
Mus musculus NCS1 MGD MGI:109166