IL17B - interleukin 17B Gene

Homo sapiens

Also known as NIRF; IL-20; IL-17B; ZCYTO7

Gene ID: 27190 | Gene type: protein coding

About IL17B

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:149,374,267-149,404,202 (from NCBI)

This gene has 3 transcripts (splice variants), 137 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

IL17B Products(2)

mRNA	Protein	Name
NM_001317987.2	NP_001304916.1	interleukin-17B isoform 2
NM_014443.3	NP_055258.1	interleukin-17B isoform 1 precursor

IL17B Protein Structure

IL17

0
100
180 a.a.

Protein Preferred Names

Protein Names

interleukin-17B

cytokine-like protein ZCYTO7

Recombinant IL17B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72588	IL-17B Protein, Human (HEK293, Fc)	Q9UHF5 (Q21-F180)	≥95%
HY-P700105AF	Animal-Free IL-17B Protein, Human (His)	Q9UHF5 (Q21-F180)	≥95%

Related Diseases

Diseases

Alias

Leiomyoma

Leiomyomatous Neoplasm	Leiomyomatous Tumor
Leiomyomas	Fibroid Tumor
Uterine Fibroids

Psoriasis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06698	IL17B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990741	Galvokimig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL17B	VGNC	VGNC:102232
Canis familiaris	IL17B	VGNC	VGNC:41943
Bos taurus	IL17B	VGNC	VGNC:30118
Mus musculus	IL17B	MGD	MGI:1928397
Macaca mulatta	IL17B	VGNC	VGNC:110458
Rattus norvegicus	IL17B	RGD	RGD:620614

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