SULT1C4 - sulfotransferase family 1C member 4 Gene

Homo sapiens

Also known as SULT1C; SULT1C2

Gene ID: 27233 | Gene type: protein coding

About SULT1C4

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,377,954-108,388,989 (from NCBI)

This gene has 3 transcripts (splice variants), 256 orthologues and 12 paralogues. Broad expression in gall bladder (RPKM 13.7), ovary (RPKM 9.3) and 15 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]

SULT1C4 Products(2)

mRNA	Protein	Name
NM_001321770.2	NP_001308699.1	sulfotransferase 1C4 isoform 2
NM_006588.4	NP_006579.2	sulfotransferase 1C4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aryl sulfotransferase activity	IDA IDA: Inferred from direct assay	17425406	GOA
enables sulfotransferase activity	IDA IDA: Inferred from direct assay	20056724	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in doxorubicin metabolic process	IDA IDA: Inferred from direct assay	26948952	GOA
involved in ethanol catabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in flavonoid metabolic process	IDA IDA: Inferred from direct assay	28222028	GOA
involved in sulfation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	26948952	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	28222028	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1C4 Protein Structure

Sulfotransfer_1

0
100
200
302 a.a.

Protein Preferred Names

Protein Names

sulfotransferase 1C4

ST1C4

Recombinant SULT1C4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71342	SULT1C4 Protein, Human (His)	Q6PD90 (M1-K102)	≥95%

Related Diseases

Diseases

Alias

Ectodermal Dysplasia 1, Hypohidrotic, X-Linked

Christ-Siemens-Touraine Syndrome	XHED
Ectodermal Dysplasia 1	Xlhed
Ed1	Cst Syndrome
Ectodermal Dysplasia 1, Hypohidrotic/Hair/Tooth Type, X-Linked	Ectd1
Ectodermal Dysplasia, Anhidrotic, X-Linked	Eda
Eda1	Hed1
Ectodermal Dysplasia 1, Anhidrotic	X-Linked Anhidrotic Ectodermal Dysplasia
X-Linked Hypohidrotic Ectodermal Dysplasia	Hypohidrotic X-Linked Ectodermal Dysplasia
Ectodermal Dysplasia, Hypohidrotic, 1	Hypohidrotic Ectodermal Dysplasia, X-Linked
Anhidrotic Ectodermal Dysplasia X-Linked	Hypohidrotic Ectodermal Dysplasia X-Linked
Ectodermal Dysplasia 1 Hypohidrotic/Hair/Tooth Type X-Linked	Ectodermal Dysplasia Anhidrotic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14018	SULT1C4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SULT1C4	VGNC	VGNC:106230
Mus musculus	SULT1C4	MGD	MGI:102928
Felis catus	SULT1C4	VGNC	VGNC:65836
Canis familiaris	SULT1C4	VGNC	VGNC:46978
Others	SULT1C4	NCBI

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