TNFRSF21 - TNF receptor superfamily member 21 Gene

Homo sapiens

Also known as DR6; CD358; BM-018

Gene ID: 27242 | Gene type: protein coding

About TNFRSF21

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:47,231,532-47,309,905 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 21 paralogues. Broad expression in urinary bladder (RPKM 50.6), fat (RPKM 36.4) and 23 other tissues.

Summary

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell Apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

TNFRSF21 Products(1)

mRNA	Protein	Name
NM_014452.5	NP_055267.1	tumor necrosis factor receptor superfamily member 21 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23559013	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22761420	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	19654028	GOA
involved in negative regulation of myelination	IMP IMP: Inferred from mutant phenotype	21725297	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19654028	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF21 Protein Structure

Death

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 21

TNFR-related death receptor 6

Recombinant TNFRSF21 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72665	DR6/TNFRSF21 Protein, Human (HEK293, His)	O75509 (Q42-L350)	≥95%
HY-P72979	DR6/TNFRSF21 Protein, Human (HEK293, Fc)	O75509 (Q42-L350)	≥95%
HY-P75279	DR6/TNFRSF21 Protein, Human (HEK293)	O75509 (Q42-L350)	≥95%
HY-P700505	DR6/TNFRSF21 Protein, Human (His-SUMO)	O75509 (R371-L655)	≥95%

Related Diseases

Diseases

Alias

Diffuse Infiltrative Lymphocytosis Syndrome

Nipah Virus Encephalitis

Equine Morbillivirus

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1	DRS1
Robinow Dwarfism	Fetal Face Syndrome
Acral Dysostosis With Facial And Genital Abnormalities	Robinow, Autosomal Dominant Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14812	TNFRSF21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNFRSF21	VGNC	VGNC:78923
Rattus norvegicus	TNFRSF21	RGD	RGD:1307308
Bos taurus	TNFRSF21	VGNC	VGNC:36166
Felis catus	TNFRSF21	VGNC	VGNC:66409
Mus musculus	TNFRSF21	MGD	MGI:2151075
Macaca fascicularis	TNFRSF21	NCBI	NCBI:101925746
Others	TNFRSF21	NCBI

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