CRCP - CGRP receptor component Gene

Homo sapiens

Also known as C17; RCP; RCP9; RPC9; POLR3I; POLR3J; CGRPRCP; CGRP-RCP

Gene ID: 27297 | Gene type: protein coding

About CRCP

Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38): 7:66,114,818-66,154,568 (from NCBI)

This gene has 7 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in bone marrow (RPKM 11.5), thyroid (RPKM 11.3) and 25 other tissues.

Summary

This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CRCP Products(5)

mRNA	Protein	Name
NM_001040648.2	NP_001035738.1	DNA-directed RNA polymerase III subunit RPC9 isoform c
NR_024548.2
NM_001040647.2	NP_001035737.1	DNA-directed RNA polymerase III subunit RPC9 isoform b
NM_014478.5	NP_055293.1	DNA-directed RNA polymerase III subunit RPC9 isoform a
NM_001142414.1	NP_001135886.1	DNA-directed RNA polymerase III subunit RPC9 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-directed 5'-3' RNA polymerase activity	IDA IDA: Inferred from direct assay	12482973	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	12482973	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA polymerase III complex	IDA IDA: Inferred from direct assay	12482973	GOA
part of RNA polymerase III complex	IDA IDA: Inferred from direct assay	33335104	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRCP Protein Structure

RNA_pol_Rpb4

0
100
148 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerase III subunit RPC9

CGRP-receptor component protein	RNA polymerase III subunit C9
calcitonin gene-related peptide-receptor component protein

CRCP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CRCP	O75575	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Prey Pooling	25416956
Intra	CRCP	O75575	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
Intra	CRCP	O75575	TCF12	Homo sapiens	Q99081	Y2H Array	25416956
Intra	CRCP	O75575	ZMIZ2	Homo sapiens	Q8NF64	Y2H Prey Pooling	25416956
Intra	CRCP	O75575	ZMIZ2	Homo sapiens	Q8NF64	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

CRCP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83605	CRCP Antibody (YA3350)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Intracranial Hypertension

Raised Intracranial Pressure

Communicating Hydrocephalus

Acquired Communicating Hydrocephalus

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03144	CRCP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03145	Crcp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03146	Crcp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CRCP	VGNC	VGNC:39594
Felis catus	CRCP	VGNC	VGNC:61163
Bos taurus	CRCP	VGNC	VGNC:27691
Mus musculus	CRCP	MGD	MGI:1100818
Macaca mulatta	CRCP	VGNC	VGNC:71432
Rattus norvegicus	CRCP	RGD	RGD:620753

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