SGSM3 - small G protein signaling modulator 3 Gene

Homo sapiens

Also known as MAP; CIP85; RUSC3; RUTBC3; RABGAP5; RabGAP-5; rabGAPLP

Gene ID: 27352 | Gene type: protein coding

About SGSM3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:40,370,594-40,410,289 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 45 paralogues. Ubiquitous expression in stomach (RPKM 33.5), prostate (RPKM 23.3) and 25 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including Rap protein signal transduction; positive regulation of GTPase activity; and regulation of Rab protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SGSM3 Products(12)

mRNA	Protein	Name
NM_001301849.2	NP_001288778.1	small G protein signaling modulator 3 isoform 2
NM_001350039.2	NP_001336968.1	small G protein signaling modulator 3 isoform 3
NM_001350040.2	NP_001336969.1	small G protein signaling modulator 3 isoform 4
NM_001350041.2	NP_001336970.1	small G protein signaling modulator 3 isoform 5
NM_001350042.2	NP_001336971.1	small G protein signaling modulator 3 isoform 6
NM_001350043.2	NP_001336972.1	small G protein signaling modulator 3 isoform 7
NM_001350044.2	NP_001336973.1	small G protein signaling modulator 3 isoform 8
NM_001350045.2	NP_001336974.1	small G protein signaling modulator 3 isoform 8
NM_001350046.2	NP_001336975.1	small G protein signaling modulator 3 isoform 9
NM_001350047.2	NP_001336976.1	small G protein signaling modulator 3 isoform 10
NM_001350048.2	NP_001336977.1	small G protein signaling modulator 3 isoform 11
NM_015705.6	NP_056520.2	small G protein signaling modulator 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	17562788	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17509819	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	17509819	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	17562788	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Rap protein signal transduction	IEP IEP: Inferred from expression pattern	17509819	GOA
involved in plasma membrane to endosome transport	IMP IMP: Inferred from mutant phenotype	17562788	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	17562788	GOA
involved in regulation of Rab protein signal transduction	IEP IEP: Inferred from expression pattern	17509819	GOA
NOT involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17562788	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGSM3 Protein Structure

RabGAP-TBC

SH3_1

RUN

0
200
400
600
749 a.a.

Protein Preferred Names

Protein Names

small G protein signaling modulator 3

RUN and SH3 containing 3

Related Diseases

Diseases

Alias

Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12815	SGSM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SGSM3	VGNC	VGNC:108035
Canis familiaris	SGSM3	VGNC	VGNC:46106
Rattus norvegicus	SGSM3	RGD	RGD:735113
Mus musculus	SGSM3	MGD	MGI:1916329
Bos taurus	SGSM3	VGNC	VGNC:34552

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