GNG4 - G protein subunit gamma 4 Gene

Homo sapiens

Also known as HG3C

Gene ID: 2786 | Gene type: protein coding

About GNG4

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,547,685-235,650,608 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 181 orthologues and 11 paralogues. Biased expression in brain (RPKM 11.8), ovary (RPKM 8.0) and 8 other tissues.

Summary

Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

GNG4 Products(3)

mRNA	Protein	Name
NM_001098721.2	NP_001092191.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
NM_001098722.2	NP_001092192.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
NM_004485.4	NP_004476.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23021213	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	15824735	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG4 Protein Structure

G-gamma

0
75 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

guanine nucleotide binding protein (G protein), gamma 4

GNG4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GNG4	P50150	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05558	GNG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GNG4	MGD	MGI:102703
Rattus norvegicus	GNG4	RGD	RGD:620806
Macaca mulatta	GNG4	VGNC	VGNC:106372
Bos taurus	GNG4	VGNC	VGNC:29467
Canis familiaris	GNG4	VGNC	VGNC:51896

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